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Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta.

Publication ,  Journal Article
Buchanan, JR; Kleinstreuer, C; Hyun, S; Truskey, GA
Published in: Journal of biomechanics
August 2003

Employing the rabbit's abdominal aorta as a suitable atherosclerotic model, transient three-dimensional blood flow simulations and monocyte deposition patterns were used to evaluate the following hypotheses: (i) simulation of monocyte transport through a model of the rabbit abdominal aorta yields cell deposition patterns similar to those seen in vivo, and (ii) those deposition patterns are correlated with hemodynamic wall parameters related to atherosclerosis. The deposition pattern traces a helical shape down the aorta with local elevation in monocyte adhesion around vessel branches. The cell deposition pattern was altered by an exercise waveform with fewer cells attaching in the upper abdominal aorta but more attaching around the renal orifices. Monocyte deposition was correlated with the wall shear stress gradient and the wall shear stress angle gradient. The wall stress gradient, the wall shear stress angle gradient and the normalized monocyte deposition fraction were correlated with the distribution of monocytes along the abdominal aorta and monocyte deposition is correlated with the measured distribution of monocytes around the major abdominal branches in the cholesterol-fed rabbit. These results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions.

Duke Scholars

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

August 2003

Volume

36

Issue

8

Start / End Page

1185 / 1196

Related Subject Headings

  • Shear Strength
  • Rabbits
  • Pulsatile Flow
  • Physical Conditioning, Animal
  • Monocytes
  • Models, Cardiovascular
  • Hemorheology
  • Endothelium, Vascular
  • Elasticity
  • Coronary Artery Disease
 

Citation

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ICMJE
MLA
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Buchanan, J. R., Kleinstreuer, C., Hyun, S., & Truskey, G. A. (2003). Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta. Journal of Biomechanics, 36(8), 1185–1196. https://doi.org/10.1016/s0021-9290(03)00088-5
Buchanan, J. R., C. Kleinstreuer, S. Hyun, and G. A. Truskey. “Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta.Journal of Biomechanics 36, no. 8 (August 2003): 1185–96. https://doi.org/10.1016/s0021-9290(03)00088-5.
Buchanan JR, Kleinstreuer C, Hyun S, Truskey GA. Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta. Journal of biomechanics. 2003 Aug;36(8):1185–96.
Buchanan, J. R., et al. “Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta.Journal of Biomechanics, vol. 36, no. 8, Aug. 2003, pp. 1185–96. Epmc, doi:10.1016/s0021-9290(03)00088-5.
Buchanan JR, Kleinstreuer C, Hyun S, Truskey GA. Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta. Journal of biomechanics. 2003 Aug;36(8):1185–1196.
Journal cover image

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

August 2003

Volume

36

Issue

8

Start / End Page

1185 / 1196

Related Subject Headings

  • Shear Strength
  • Rabbits
  • Pulsatile Flow
  • Physical Conditioning, Animal
  • Monocytes
  • Models, Cardiovascular
  • Hemorheology
  • Endothelium, Vascular
  • Elasticity
  • Coronary Artery Disease