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Universal route to cell micropatterning using an amphiphilic comb polymer

Publication ,  Journal Article
Hyun, J; Ma, H; Zhang, Z; Beebe Jr, TP; Chilkoti, A
Published in: Advanced Materials
2003

Micropatterning of localized chemical or biochemical domains has the potential to become a powerful tool to control the behavior of anchorage-dependent cells. However, several problems, such as the limited types of substrates that can be successfully patterned with cells and the lack of reliable, long-term retention of cellular patterns under physiological conditions need to be solved for cellular patterning to become widely applicable for cell-based biosensors, biomaterials, and high-throughput drug screening assay. This paper reports on a simple and generic method to micropattern surfaces with an amphiphilic comb polymer presenting short oligoethylene glycol side chains that enables long-term, spatially resolved attachment and growth of mammalian cells in a biologically relevant milieu on a variety of substrates.

Duke Scholars

Published In

Advanced Materials

DOI

Publication Date

2003

Volume

15

Issue

7-8

Start / End Page

576 / 579

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hyun, J., Ma, H., Zhang, Z., Beebe Jr, T. P., & Chilkoti, A. (2003). Universal route to cell micropatterning using an amphiphilic comb polymer. Advanced Materials, 15(7–8), 576–579. https://doi.org/10.1002/adma.200304496
Hyun, Jinho, Hongwei Ma, Zhanping Zhang, Thomas P. Beebe Jr, and Ashutosh Chilkoti. “Universal route to cell micropatterning using an amphiphilic comb polymer.” Advanced Materials 15, no. 7–8 (2003): 576–79. https://doi.org/10.1002/adma.200304496.
Hyun J, Ma H, Zhang Z, Beebe Jr TP, Chilkoti A. Universal route to cell micropatterning using an amphiphilic comb polymer. Advanced Materials. 2003;15(7–8):576–9.
Hyun, Jinho, et al. “Universal route to cell micropatterning using an amphiphilic comb polymer.” Advanced Materials, vol. 15, no. 7–8, 2003, pp. 576–79. Manual, doi:10.1002/adma.200304496.
Hyun J, Ma H, Zhang Z, Beebe Jr TP, Chilkoti A. Universal route to cell micropatterning using an amphiphilic comb polymer. Advanced Materials. 2003;15(7–8):576–579.

Published In

Advanced Materials

DOI

Publication Date

2003

Volume

15

Issue

7-8

Start / End Page

576 / 579

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences