Microstamping of a biological ligand onto an activated polymer surface

A method for patterning biological ligands and proteins were patterned onto polymer surfaces is described. Called microstamping onto an activated polymer surface (MAPS), the method is based on a reaction between a microcontact-printed biological ligand and the surface of a polymer that has been derivatized to react specifically with the ligand. Using biotin ligands and polyethylene terephthalate, the method was demonstrated to yield a spatial resolution of at least 5 µm, high contrast and good reproducibility.

Duke Scholars

Author Ashutosh Chilkoti Biomedical Engineering