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Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery.

Publication ,  Journal Article
Chilkoti, A; Dreher, MR; Meyer, DE
Published in: Advanced drug delivery reviews
October 2002

In this article, we review recombinant DNA methods for the design and synthesis of amino acid-based biopolymers, and briefly summarize an approach, recursive directional ligation (RDL), that we have employed to synthesize oligomeric genes for such biopolymers. We then describe our ongoing research in the use of RDL to synthesize recombinant polypeptide carriers for the targeted delivery of radionuclides, chemotherapeutics and biomolecular therapeutics to tumors. The targeted delivery system uses a thermally responsive, elastin-like polypeptide (ELP) as the drug carrier to enhance the localization of ELP-drug conjugates within a solid tumor that is heated by regional hyperthermia. In the context of this drug delivery application, we discuss the design of ELPs and their recombinant synthesis, which enables the molecular weight and the thermal properties of the polypeptide to be precisely controlled. Finally, our results pertaining to the in vivo targeting of tumors with ELPs are briefly summarized.

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

October 2002

Volume

54

Issue

8

Start / End Page

1093 / 1111

Related Subject Headings

  • Sequence Analysis, Protein
  • Recombinant Proteins
  • Pharmacology & Pharmacy
  • Peptides
  • Molecular Sequence Data
  • Drug Design
  • Drug Delivery Systems
  • Drug Carriers
  • Base Sequence
  • Amino Acid Sequence
 

Citation

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ICMJE
MLA
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Chilkoti, A., Dreher, M. R., & Meyer, D. E. (2002). Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Advanced Drug Delivery Reviews, 54(8), 1093–1111. https://doi.org/10.1016/s0169-409x(02)00060-1
Chilkoti, Ashutosh, Matthew R. Dreher, and Dan E. Meyer. “Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery.Advanced Drug Delivery Reviews 54, no. 8 (October 2002): 1093–1111. https://doi.org/10.1016/s0169-409x(02)00060-1.
Chilkoti A, Dreher MR, Meyer DE. Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Advanced drug delivery reviews. 2002 Oct;54(8):1093–111.
Chilkoti, Ashutosh, et al. “Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery.Advanced Drug Delivery Reviews, vol. 54, no. 8, Oct. 2002, pp. 1093–111. Epmc, doi:10.1016/s0169-409x(02)00060-1.
Chilkoti A, Dreher MR, Meyer DE. Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Advanced drug delivery reviews. 2002 Oct;54(8):1093–1111.
Journal cover image

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

October 2002

Volume

54

Issue

8

Start / End Page

1093 / 1111

Related Subject Headings

  • Sequence Analysis, Protein
  • Recombinant Proteins
  • Pharmacology & Pharmacy
  • Peptides
  • Molecular Sequence Data
  • Drug Design
  • Drug Delivery Systems
  • Drug Carriers
  • Base Sequence
  • Amino Acid Sequence