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Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry.

Publication ,  Journal Article
Oleson, JR; Assaad, A; Dewhirst, MW; DeYoung, DW; Grochowski, KJ; Sim, DA
Published in: Radiat Res
June 1984

We have investigated magnetic induction heating techniques for achieving normal tissue hyperthermia in a beagle dog model to clarify the physics and physiology of "regional heating," to develop an animal model of regional heating in humans, and to develop a method of rapid regional heating in dogs for a normal visceral tissue toxicity study. Heating was done with a concentric coil or a coaxial pair of coils applied to the abdominal region, and with or without surface cooling blankets in each case. Thermometers were placed at multiple visceral and subcutaneous sites including an intraarterial thermocouple at the aortic arch level. With either electrode arrangement and no surface cooling, whole-body hyperthermia ( WBH ) at 42 degrees C was produced within 30 to 55 min with 250 W applied power; the 42 degrees C state could be maintained with 40 to 60 W of power. Thermal gradients in these cases reflected nonuniform power deposition superimposed upon arterial temperature elevation. With surface cooling blankets added, systemic heating was significantly reduced, and temperature gradients again reflected the nonuniform power deposition. Regional heating in a dog produces WBH unless sufficient surface cooling is used to provide a heat dissipation rate balancing the heat absorption rate; this latter case best models the use of inductive techniques in humans. The coaxial pair of coils, without surface cooling, produced rapid WBH and the visceral temperature maximum and minimum were within Tesoph + 0.21 degrees C and Tesoph - 0.07 degrees C, respectively (95% confidence index; Tesoph = esophageal temperature). This is an appropriate technique for the proposed toxicity study.

Duke Scholars

Published In

Radiat Res

ISSN

0033-7587

Publication Date

June 1984

Volume

98

Issue

3

Start / End Page

445 / 455

Location

United States

Related Subject Headings

  • Time Factors
  • Thermometers
  • Thermal Conductivity
  • Oncology & Carcinogenesis
  • Magnetics
  • Hyperthermia, Induced
  • Heating
  • Female
  • Electrodes
  • Dogs
 

Citation

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Oleson, J. R., Assaad, A., Dewhirst, M. W., DeYoung, D. W., Grochowski, K. J., & Sim, D. A. (1984). Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry. Radiat Res, 98(3), 445–455.
Oleson, J. R., A. Assaad, M. W. Dewhirst, D. W. DeYoung, K. J. Grochowski, and D. A. Sim. “Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry.Radiat Res 98, no. 3 (June 1984): 445–55.
Oleson JR, Assaad A, Dewhirst MW, DeYoung DW, Grochowski KJ, Sim DA. Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry. Radiat Res. 1984 Jun;98(3):445–55.
Oleson, J. R., et al. “Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry.Radiat Res, vol. 98, no. 3, June 1984, pp. 445–55.
Oleson JR, Assaad A, Dewhirst MW, DeYoung DW, Grochowski KJ, Sim DA. Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry. Radiat Res. 1984 Jun;98(3):445–455.

Published In

Radiat Res

ISSN

0033-7587

Publication Date

June 1984

Volume

98

Issue

3

Start / End Page

445 / 455

Location

United States

Related Subject Headings

  • Time Factors
  • Thermometers
  • Thermal Conductivity
  • Oncology & Carcinogenesis
  • Magnetics
  • Hyperthermia, Induced
  • Heating
  • Female
  • Electrodes
  • Dogs