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Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.

Publication ,  Journal Article
Secomb, TW; Hsu, R; Ong, ET; Gross, JF; Dewhirst, MW
Published in: Acta Oncol
1995

The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30%. Hypoxia is abolished by a reduction in consumption rate of at least 30%, relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.

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Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

1995

Volume

34

Issue

3

Start / End Page

313 / 316

Location

Sweden

Related Subject Headings

  • Skin
  • Regional Blood Flow
  • Rats, Inbred F344
  • Rats
  • Partial Pressure
  • Oxygen Consumption
  • Oxygen
  • Oncology & Carcinogenesis
  • Models, Cardiovascular
  • Microcirculation
 

Citation

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MLA
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Secomb, T. W., Hsu, R., Ong, E. T., Gross, J. F., & Dewhirst, M. W. (1995). Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol, 34(3), 313–316. https://doi.org/10.3109/02841869509093981
Secomb, T. W., R. Hsu, E. T. Ong, J. F. Gross, and M. W. Dewhirst. “Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.Acta Oncol 34, no. 3 (1995): 313–16. https://doi.org/10.3109/02841869509093981.
Secomb TW, Hsu R, Ong ET, Gross JF, Dewhirst MW. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 1995;34(3):313–6.
Secomb, T. W., et al. “Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.Acta Oncol, vol. 34, no. 3, 1995, pp. 313–16. Pubmed, doi:10.3109/02841869509093981.
Secomb TW, Hsu R, Ong ET, Gross JF, Dewhirst MW. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 1995;34(3):313–316.
Journal cover image

Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

1995

Volume

34

Issue

3

Start / End Page

313 / 316

Location

Sweden

Related Subject Headings

  • Skin
  • Regional Blood Flow
  • Rats, Inbred F344
  • Rats
  • Partial Pressure
  • Oxygen Consumption
  • Oxygen
  • Oncology & Carcinogenesis
  • Models, Cardiovascular
  • Microcirculation