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Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin

Publication ,  Journal Article
Pogue, BW; Braun, RD; Lanzen, JL; Erickson, C; Dewhirst, MW
Published in: Proceedings of SPIE the International Society for Optical Engineering
January 1, 2001
Published version (DOI)

Measurements of tissue oxygen partial pressure (pO2), blood flow and blood pressure were recorded in rat mammary R3230Ac tumors during treatment with verteporfin-based photodynamic therapy. Microelectrodes of 12 micron tip diameter were used in a fixed position throughout the measurements to provide data on the temporal changes at a single location within the tissue. The microelectrode signal changes in pO2 indicated an overall trend to acute loss of pO2 after treatment, but with some notable exceptions where the pO2 did not decrease either during the treatment or after treatment. These regions which showed little change in pO2 were correlated with locations in which the pO2 was high to begin with before the initiation of treatment. Blood flow decreased during treatment, with the dominant effect immediately upon the initiation of treatment.

Duke Scholars

Mark Wesley Dewhirst
Author Mark Wesley Dewhirst Radiation Oncology

Published In

Proceedings of SPIE the International Society for Optical Engineering

DOI

10.1117/12.424446

ISSN

0277-786X

Publication Date

January 1, 2001

Volume

4248

Start / End Page

144 / 149

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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ICMJE
MLA
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Pogue, B. W., Braun, R. D., Lanzen, J. L., Erickson, C., & Dewhirst, M. W. (2001). Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin. Proceedings of SPIE the International Society for Optical Engineering, 4248, 144–149. https://doi.org/10.1117/12.424446
Pogue, B. W., R. D. Braun, J. L. Lanzen, C. Erickson, and M. W. Dewhirst. “Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin.” Proceedings of SPIE the International Society for Optical Engineering 4248 (January 1, 2001): 144–49. https://doi.org/10.1117/12.424446.
Pogue BW, Braun RD, Lanzen JL, Erickson C, Dewhirst MW. Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin. Proceedings of SPIE the International Society for Optical Engineering. 2001 Jan 1;4248:144–9.
Pogue, B. W., et al. “Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin.” Proceedings of SPIE the International Society for Optical Engineering, vol. 4248, Jan. 2001, pp. 144–49. Scopus, doi:10.1117/12.424446.
Pogue BW, Braun RD, Lanzen JL, Erickson C, Dewhirst MW. Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin. Proceedings of SPIE the International Society for Optical Engineering. 2001 Jan 1;4248:144–149.

Published In

Proceedings of SPIE the International Society for Optical Engineering

DOI

10.1117/12.424446

ISSN

0277-786X

Publication Date

January 1, 2001

Volume

4248

Start / End Page

144 / 149

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering