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Patency and blood flow in gas denucleated arterial prostheses.

Publication ,  Journal Article
Vann, RD; Ritter, EF; Plunkett, MD; Wyble, CW; Bensen, CV; Gerth, WA; Barwick, WJ; Klitzman, B
Published in: J Biomed Mater Res
April 1993

Biomaterials exposed to blood often fail due to thrombosis. Gas nuclei (air) in the material are thrombogenic and a potential cause of failure. The effects of gas nuclei on patency and blood flow were studied in 4 mm diameter arterial grafts (Gore ePTFE; Johnson and Johnson Vitagraft ePTFE; Bard ACG EXS) in the femoropopliteal position of dogs. Control and denucleated (air-free) grafts were implanted bilaterally. Grafts were denucleated by immersion in degassed saline and exposure to 4 torr vacuum and 3,000-20,000 psig pressure. Graft patency was determined at harvest in 46 dogs. Blood flow was measured with acoustic flow probes in eight dogs. Denucleated graft patency was 60% after 2 days of implant while control patency was 22% (P < .05). Measured blood flow was higher in denucleated grafts than in control grafts (P < .02) in 4 of 5 dogs which had significantly different flows. Patency and flow decreased to zero for both control and denucleated grafts over periods of up to 80 days. Air in the control grafts may have been absorbed within several days, leading to late similarity with the denucleated grafts. Thus, removing the air from 4 mm ePTFE grafts decreased acute thrombosis and increased the patency.

Duke Scholars

Published In

J Biomed Mater Res

DOI

ISSN

0021-9304

Publication Date

April 1993

Volume

27

Issue

4

Start / End Page

493 / 498

Location

United States

Related Subject Headings

  • Vascular Patency
  • Time Factors
  • Regional Blood Flow
  • Polytetrafluoroethylene
  • Polyethylene Terephthalates
  • Femoral Artery
  • Dogs
  • Blood Vessel Prosthesis
  • Biomedical Engineering
  • Biocompatible Materials
 

Citation

APA
Chicago
ICMJE
MLA
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Vann, R. D., Ritter, E. F., Plunkett, M. D., Wyble, C. W., Bensen, C. V., Gerth, W. A., … Klitzman, B. (1993). Patency and blood flow in gas denucleated arterial prostheses. J Biomed Mater Res, 27(4), 493–498. https://doi.org/10.1002/jbm.820270410
Vann, R. D., E. F. Ritter, M. D. Plunkett, C. W. Wyble, C. V. Bensen, W. A. Gerth, W. J. Barwick, and B. Klitzman. “Patency and blood flow in gas denucleated arterial prostheses.J Biomed Mater Res 27, no. 4 (April 1993): 493–98. https://doi.org/10.1002/jbm.820270410.
Vann RD, Ritter EF, Plunkett MD, Wyble CW, Bensen CV, Gerth WA, et al. Patency and blood flow in gas denucleated arterial prostheses. J Biomed Mater Res. 1993 Apr;27(4):493–8.
Vann, R. D., et al. “Patency and blood flow in gas denucleated arterial prostheses.J Biomed Mater Res, vol. 27, no. 4, Apr. 1993, pp. 493–98. Pubmed, doi:10.1002/jbm.820270410.
Vann RD, Ritter EF, Plunkett MD, Wyble CW, Bensen CV, Gerth WA, Barwick WJ, Klitzman B. Patency and blood flow in gas denucleated arterial prostheses. J Biomed Mater Res. 1993 Apr;27(4):493–498.

Published In

J Biomed Mater Res

DOI

ISSN

0021-9304

Publication Date

April 1993

Volume

27

Issue

4

Start / End Page

493 / 498

Location

United States

Related Subject Headings

  • Vascular Patency
  • Time Factors
  • Regional Blood Flow
  • Polytetrafluoroethylene
  • Polyethylene Terephthalates
  • Femoral Artery
  • Dogs
  • Blood Vessel Prosthesis
  • Biomedical Engineering
  • Biocompatible Materials