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Development of a 4-D digital mouse phantom for molecular imaging research.

Publication ,  Journal Article
Segars, WP; Tsui, BMW; Frey, EC; Johnson, GA; Berr, SS
Published in: Mol Imaging Biol
2004
Published version (DOI) Link to item

PURPOSE: We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research. METHODS: Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained from normal mice. Pilot simulation studies in single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) were performed to demonstrate the utility of the phantom. RESULTS: NURBS are an efficient and flexible way to accurately model the anatomy and cardiac and respiratory motions for a realistic 4-D digital mouse phantom. The phantom is capable of producing realistic molecular imaging data from which imaging devices and techniques can be evaluated. CONCLUSION: The phantom provides a unique and useful tool in molecular imaging research. It can be used in the development of new imaging instrumentation, image acquisition strategies, and image processing and reconstruction methods.

Duke Scholars

William Paul Segars
Author William Paul Segars Radiology
G. Allan Johnson
Author G. Allan Johnson Radiology
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Published In

Mol Imaging Biol

DOI

10.1016/j.mibio.2004.03.002

ISSN

1536-1632

Publication Date

2004

Volume

6

Issue

3

Start / End Page

149 / 159

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Models, Animal
  • Models, Anatomic
  • Mice
  • Image Processing, Computer-Assisted
  • Animals
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Segars, W. P., Tsui, B. M. W., Frey, E. C., Johnson, G. A., & Berr, S. S. (2004). Development of a 4-D digital mouse phantom for molecular imaging research. Mol Imaging Biol, 6(3), 149–159. https://doi.org/10.1016/j.mibio.2004.03.002
Segars, William P., Benjamin M. W. Tsui, Eric C. Frey, G Allan Johnson, and Stuart S. Berr. “Development of a 4-D digital mouse phantom for molecular imaging research.” Mol Imaging Biol 6, no. 3 (2004): 149–59. https://doi.org/10.1016/j.mibio.2004.03.002.
Segars WP, Tsui BMW, Frey EC, Johnson GA, Berr SS. Development of a 4-D digital mouse phantom for molecular imaging research. Mol Imaging Biol. 2004;6(3):149–59.
Segars, William P., et al. “Development of a 4-D digital mouse phantom for molecular imaging research.” Mol Imaging Biol, vol. 6, no. 3, 2004, pp. 149–59. Pubmed, doi:10.1016/j.mibio.2004.03.002.
Segars WP, Tsui BMW, Frey EC, Johnson GA, Berr SS. Development of a 4-D digital mouse phantom for molecular imaging research. Mol Imaging Biol. 2004;6(3):149–159.
Journal cover image

Published In

Mol Imaging Biol

DOI

10.1016/j.mibio.2004.03.002

ISSN

1536-1632

Publication Date

2004

Volume

6

Issue

3

Start / End Page

149 / 159

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Models, Animal
  • Models, Anatomic
  • Mice
  • Image Processing, Computer-Assisted
  • Animals
  • 3202 Clinical sciences