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Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.

Publication ,  Journal Article
Wassenberg, DM; Di Giulio, RT
Published in: Marine environmental research
August 2004

The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.

Duke Scholars

Published In

Marine environmental research

DOI

EISSN

1879-0291

ISSN

0141-1136

Publication Date

August 2004

Volume

58

Issue

2-5

Start / End Page

163 / 168

Related Subject Headings

  • Virginia
  • Tail
  • Piperonyl Butoxide
  • Ovum
  • Marine Biology & Hydrobiology
  • Heart Defects, Congenital
  • Geologic Sediments
  • Fundulidae
  • Fresh Water
  • Fluorenes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wassenberg, D. M., & Di Giulio, R. T. (2004). Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine Environmental Research, 58(2–5), 163–168. https://doi.org/10.1016/j.marenvres.2004.03.012
Wassenberg, Deena M., and Richard T. Di Giulio. “Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.Marine Environmental Research 58, no. 2–5 (August 2004): 163–68. https://doi.org/10.1016/j.marenvres.2004.03.012.
Wassenberg DM, Di Giulio RT. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine environmental research. 2004 Aug;58(2–5):163–8.
Wassenberg, Deena M., and Richard T. Di Giulio. “Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.Marine Environmental Research, vol. 58, no. 2–5, Aug. 2004, pp. 163–68. Epmc, doi:10.1016/j.marenvres.2004.03.012.
Wassenberg DM, Di Giulio RT. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine environmental research. 2004 Aug;58(2–5):163–168.
Journal cover image

Published In

Marine environmental research

DOI

EISSN

1879-0291

ISSN

0141-1136

Publication Date

August 2004

Volume

58

Issue

2-5

Start / End Page

163 / 168

Related Subject Headings

  • Virginia
  • Tail
  • Piperonyl Butoxide
  • Ovum
  • Marine Biology & Hydrobiology
  • Heart Defects, Congenital
  • Geologic Sediments
  • Fundulidae
  • Fresh Water
  • Fluorenes