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Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999.

Publication ,  Journal Article
Boydell, J; van Os, J; Caspi, A; Kennedy, N; Giouroukou, E; Fearon, P; Farrell, M; Murray, RM
Published in: Psychological medicine
October 2006

There is evidence that cannabis use might be relevant to the aetiology of schizophrenia. We aimed to measure any change in cannabis use over time in those first presenting with schizophrenia in South-East London from 1965 to 1999, and compare this with change in use in those presenting with non-psychotic psychiatric disorders.The rate of cannabis use in the year prior to first ever presentation was measured over seven time periods. Logistic regression modelling was used to determine (a) whether cannabis use changed over time, after controlling for age, sex and ethnicity, and (b) whether there was an interaction between diagnosis and time.Cannabis use increased over time in both the schizophrenia group [odds ratio per time period (OR) 2.03, 95% confidence interval (CI) 1.74-2.38, p<0.0001] and the non-psychotic disorders group (OR 1.24, 95% CI 1.05-1.47, p=0.012), after controlling for age, sex and ethnicity. However, the effect of time was significantly greater in the schizophrenia group than in the non-schizophrenia group (chi2=17, p<0.0001).Cannabis use in the year prior to presentation with schizophrenia increased markedly between 1965 and 1999, and disproportionately so compared to increase in cannabis use in other psychiatric disorders.

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Published In

Psychological medicine

DOI

EISSN

1469-8978

ISSN

0033-2917

Publication Date

October 2006

Volume

36

Issue

10

Start / End Page

1441 / 1446

Related Subject Headings

  • Schizophrenia
  • Psychiatry
  • Prevalence
  • Marijuana Abuse
  • Male
  • Incidence
  • Humans
  • Female
  • England
  • Comorbidity
 

Citation

APA
Chicago
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Boydell, J., van Os, J., Caspi, A., Kennedy, N., Giouroukou, E., Fearon, P., … Murray, R. M. (2006). Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999. Psychological Medicine, 36(10), 1441–1446. https://doi.org/10.1017/s0033291706008440
Boydell, J., J. van Os, A. Caspi, N. Kennedy, E. Giouroukou, P. Fearon, M. Farrell, and R. M. Murray. “Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999.Psychological Medicine 36, no. 10 (October 2006): 1441–46. https://doi.org/10.1017/s0033291706008440.
Boydell J, van Os J, Caspi A, Kennedy N, Giouroukou E, Fearon P, et al. Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999. Psychological medicine. 2006 Oct;36(10):1441–6.
Boydell, J., et al. “Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999.Psychological Medicine, vol. 36, no. 10, Oct. 2006, pp. 1441–46. Epmc, doi:10.1017/s0033291706008440.
Boydell J, van Os J, Caspi A, Kennedy N, Giouroukou E, Fearon P, Farrell M, Murray RM. Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999. Psychological medicine. 2006 Oct;36(10):1441–1446.
Journal cover image

Published In

Psychological medicine

DOI

EISSN

1469-8978

ISSN

0033-2917

Publication Date

October 2006

Volume

36

Issue

10

Start / End Page

1441 / 1446

Related Subject Headings

  • Schizophrenia
  • Psychiatry
  • Prevalence
  • Marijuana Abuse
  • Male
  • Incidence
  • Humans
  • Female
  • England
  • Comorbidity