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Role of genotype in the cycle of violence in maltreated children.

Publication ,  Journal Article
Caspi, A; McClay, J; Moffitt, TE; Mill, J; Martin, J; Craig, IW; Taylor, A; Poulton, R
Published in: Science (New York, N.Y.)
August 2002

We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2002

Volume

297

Issue

5582

Start / End Page

851 / 854

Related Subject Headings

  • Violence
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Male
  • Longitudinal Studies
  • Humans
  • Genotype
  • Genetics, Behavioral
 

Citation

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Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., … Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science (New York, N.Y.), 297(5582), 851–854. https://doi.org/10.1126/science.1072290
Caspi, Avshalom, Joseph McClay, Terrie E. Moffitt, Jonathan Mill, Judy Martin, Ian W. Craig, Alan Taylor, and Richie Poulton. “Role of genotype in the cycle of violence in maltreated children.Science (New York, N.Y.) 297, no. 5582 (August 2002): 851–54. https://doi.org/10.1126/science.1072290.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, et al. Role of genotype in the cycle of violence in maltreated children. Science (New York, NY). 2002 Aug;297(5582):851–4.
Caspi, Avshalom, et al. “Role of genotype in the cycle of violence in maltreated children.Science (New York, N.Y.), vol. 297, no. 5582, Aug. 2002, pp. 851–54. Epmc, doi:10.1126/science.1072290.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science (New York, NY). 2002 Aug;297(5582):851–854.

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2002

Volume

297

Issue

5582

Start / End Page

851 / 854

Related Subject Headings

  • Violence
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Male
  • Longitudinal Studies
  • Humans
  • Genotype
  • Genetics, Behavioral