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Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems.

Publication ,  Journal Article
Jaffee, SR; Caspi, A; Moffitt, TE; Dodge, KA; Rutter, M; Taylor, A; Tully, LA
Published in: Development and psychopathology
January 2005

Maltreatment places children at risk for psychiatric morbidity, especially conduct problems. However, not all maltreated children develop conduct problems. We tested whether the effect of physical maltreatment on risk for conduct problems was strongest among those who were at high genetic risk for these problems using data from the E-risk Study, a representative cohort of 1,116 5-year-old British twin pairs and their families. Children's conduct problems were ascertained via parent and teacher interviews. Physical maltreatment was ascertained via parent report. Children's genetic risk for conduct problems was estimated as a function of their co-twin's conduct disorder status and the pair's zygosity. The effect of maltreatment on risk for conduct problems was strongest among those at high genetic risk. The experience of maltreatment was associated with an increase of 2% in the probability of a conduct disorder diagnosis among children at low genetic risk for conduct disorder but an increase of 24% among children at high genetic risk. Prediction of behavioral pathology can attain greater accuracy if both pathogenic environments and genetic risk are ascertained. Certain genotypes may promote resistance to trauma. Physically maltreated children whose first-degree relatives engage in antisocial behavior warrant priority for therapeutic intervention.

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Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

January 2005

Volume

17

Issue

1

Start / End Page

67 / 84

Related Subject Headings

  • Social Environment
  • Risk Factors
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Diseases in Twins
 

Citation

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Jaffee, S. R., Caspi, A., Moffitt, T. E., Dodge, K. A., Rutter, M., Taylor, A., & Tully, L. A. (2005). Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Development and Psychopathology, 17(1), 67–84. https://doi.org/10.1017/s0954579405050042
Jaffee, Sara R., Avshalom Caspi, Terrie E. Moffitt, Kenneth A. Dodge, Michael Rutter, Alan Taylor, and Lucy A. Tully. “Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems.Development and Psychopathology 17, no. 1 (January 2005): 67–84. https://doi.org/10.1017/s0954579405050042.
Jaffee SR, Caspi A, Moffitt TE, Dodge KA, Rutter M, Taylor A, et al. Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Development and psychopathology. 2005 Jan;17(1):67–84.
Jaffee, Sara R., et al. “Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems.Development and Psychopathology, vol. 17, no. 1, Jan. 2005, pp. 67–84. Epmc, doi:10.1017/s0954579405050042.
Jaffee SR, Caspi A, Moffitt TE, Dodge KA, Rutter M, Taylor A, Tully LA. Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Development and psychopathology. 2005 Jan;17(1):67–84.
Journal cover image

Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

January 2005

Volume

17

Issue

1

Start / End Page

67 / 84

Related Subject Headings

  • Social Environment
  • Risk Factors
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Diseases in Twins