Skip to main content

Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.

Publication ,  Journal Article
Auten, RL; Mason, SN; Tanaka, DT; Welty-Wolf, K; Whorton, MH
Published in: Am J Physiol Lung Cell Mol Physiol
August 2001

Inflammation may contribute to lung injury and impaired alveolar development in bronchopulmonary dysplasia. We treated hyperoxia-exposed newborn rats with antibodies to the neutrophil chemokine cytokine-induced neutrophil chemoattractant-1 (CINC-1) during 95% O2 exposure to reduce adverse effects of hyperoxia-induced inflammation on lung development. Rats were exposed at birth to air, 95% O2, or 95% O2 + anti-CINC-1 (injected on days 3 and 4). Bromodeoxyuridine (BrdU) was injected 6 h before death. Anti-CINC-1 treatment improved weight gain but not survival at day 8. Anti-CINC-1 reduced bronchoalveolar lavage neutrophils at day 8 to levels equal to air controls. Total detectable lung CINC-1 was reduced to air control levels. Lung compliance was improved by anti-CINC-1, achieving air control levels in the 10-microg anti-CINC-1 group. Anti-CINC-1 preserved proliferating cell nuclear antigen expression in airway epithelium despite 95% O2 exposure. BrdU incorporation was depressed by hyperoxia but preserved by anti-CINC-1 to levels similar to air control. Alveolar volume and surface density were decreased by hyperoxia but preserved by anti-CINC-1 to levels equal to air control. Blockade of neutrophil influx in newborns may avert early lung injury and avoid alveolar developmental arrest that contributes to bronchopulmonary dysplasia.

Duke Scholars

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

August 2001

Volume

281

Issue

2

Start / End Page

L336 / L344

Location

United States

Related Subject Headings

  • Weight Gain
  • Survival Analysis
  • Respiratory System
  • Rats
  • Pulmonary Alveoli
  • Proliferating Cell Nuclear Antigen
  • Neutrophils
  • Lung
  • Leukocyte Count
  • Intercellular Signaling Peptides and Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Auten, R. L., Mason, S. N., Tanaka, D. T., Welty-Wolf, K., & Whorton, M. H. (2001). Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. Am J Physiol Lung Cell Mol Physiol, 281(2), L336–L344. https://doi.org/10.1152/ajplung.2001.281.2.L336
Auten, R. L., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.Am J Physiol Lung Cell Mol Physiol 281, no. 2 (August 2001): L336–44. https://doi.org/10.1152/ajplung.2001.281.2.L336.
Auten RL, Mason SN, Tanaka DT, Welty-Wolf K, Whorton MH. Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L336–44.
Auten, R. L., et al. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.Am J Physiol Lung Cell Mol Physiol, vol. 281, no. 2, Aug. 2001, pp. L336–44. Pubmed, doi:10.1152/ajplung.2001.281.2.L336.
Auten RL, Mason SN, Tanaka DT, Welty-Wolf K, Whorton MH. Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L336–L344.

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

August 2001

Volume

281

Issue

2

Start / End Page

L336 / L344

Location

United States

Related Subject Headings

  • Weight Gain
  • Survival Analysis
  • Respiratory System
  • Rats
  • Pulmonary Alveoli
  • Proliferating Cell Nuclear Antigen
  • Neutrophils
  • Lung
  • Leukocyte Count
  • Intercellular Signaling Peptides and Proteins