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The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.

Publication ,  Journal Article
Ghosh, S; Langefeld, CD; Ally, D; Watanabe, RM; Hauser, ER; Magnuson, VL; Nylund, SJ; Valle, T; Eriksson, J; Bergman, RN; Tuomilehto, J ...
Published in: Diabetologia
February 1999

Recent studies have suggested an association between Type II (non-insulin-dependent) diabetes mellitus-related phenotypes and a cytosine-to-thymidine substitution that results in the replacement of tryptophan by arginine at codon 64 (Trp64Arg or W64R) of the beta3-adrenergic receptor gene. Here, we present the results of possibly the largest association study to date on the variant in a sample of 526 families with a total of 1725 subjects, 1053 of whom had Type II diabetes. Preliminary calculations suggested that we had excellent power to detect the moderate associations which were reported in previous studies. No associations were found between the W64R variant and the following phenotypes in our sample: Type II diabetes, age at diagnosis for Type II diabetes, measures of obesity, fasting glucose, fasting insulin, minimal model variables, and systolic and diastolic blood pressures. In the analysis of plasma lipids, we detected an association between the variant and HDL ratios (HDL cholesterol/total cholesterol) (p = 0.013), which remained significant even after adjusting for sex, affection status and age. Since W64R homozygotes (n = 11) had the highest HDL ratios, however, heterozygotes had the lowest and the wild-type subjects had intermediate values, we conclude that the W64R variant is unlikely to reduce HDL ratios in a dose-dependent, pathogenic manner.

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Published In

Diabetologia

DOI

ISSN

0012-186X

Publication Date

February 1999

Volume

42

Issue

2

Start / End Page

238 / 244

Location

Germany

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Phenotype
  • Obesity
  • Mutation, Missense
  • Middle Aged
  • Male
  • Insulin
  • Humans
  • Finland
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Ghosh, S., Langefeld, C. D., Ally, D., Watanabe, R. M., Hauser, E. R., Magnuson, V. L., … Boehnke, M. (1999). The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. Diabetologia, 42(2), 238–244. https://doi.org/10.1007/s001250051144
Ghosh, S., C. D. Langefeld, D. Ally, R. M. Watanabe, E. R. Hauser, V. L. Magnuson, S. J. Nylund, et al. “The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.Diabetologia 42, no. 2 (February 1999): 238–44. https://doi.org/10.1007/s001250051144.
Ghosh S, Langefeld CD, Ally D, Watanabe RM, Hauser ER, Magnuson VL, et al. The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. Diabetologia. 1999 Feb;42(2):238–44.
Ghosh, S., et al. “The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.Diabetologia, vol. 42, no. 2, Feb. 1999, pp. 238–44. Pubmed, doi:10.1007/s001250051144.
Ghosh S, Langefeld CD, Ally D, Watanabe RM, Hauser ER, Magnuson VL, Nylund SJ, Valle T, Eriksson J, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. Diabetologia. 1999 Feb;42(2):238–244.
Journal cover image

Published In

Diabetologia

DOI

ISSN

0012-186X

Publication Date

February 1999

Volume

42

Issue

2

Start / End Page

238 / 244

Location

Germany

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Phenotype
  • Obesity
  • Mutation, Missense
  • Middle Aged
  • Male
  • Insulin
  • Humans
  • Finland
  • Female