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A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

Publication ,  Journal Article
Ghosh, S; Hauser, ER; Magnuson, VL; Valle, T; Ally, DS; Karanjawala, ZE; Rayman, JB; Knapp, JI; Musick, A; Tannenbaum, J; Te, C; Eldridge, W ...
Published in: J Clin Invest
August 15, 1998

In the first reported positive result from a genome scan for non-insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of lambdas (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score /= 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

August 15, 1998

Volume

102

Issue

4

Start / End Page

704 / 709

Location

United States

Related Subject Headings

  • White People
  • Nuclear Family
  • Middle Aged
  • Male
  • Lod Score
  • Likelihood Functions
  • Immunology
  • Humans
  • Genotype
  • Genetic Markers
 

Citation

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Ghosh, S., Hauser, E. R., Magnuson, V. L., Valle, T., Ally, D. S., Karanjawala, Z. E., … Boehnke, M. (1998). A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. J Clin Invest, 102(4), 704–709. https://doi.org/10.1172/JCI2512
Ghosh, S., E. R. Hauser, V. L. Magnuson, T. Valle, D. S. Ally, Z. E. Karanjawala, J. B. Rayman, et al. “A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.J Clin Invest 102, no. 4 (August 15, 1998): 704–9. https://doi.org/10.1172/JCI2512.
Ghosh S, Hauser ER, Magnuson VL, Valle T, Ally DS, Karanjawala ZE, et al. A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. J Clin Invest. 1998 Aug 15;102(4):704–9.
Ghosh, S., et al. “A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.J Clin Invest, vol. 102, no. 4, Aug. 1998, pp. 704–09. Pubmed, doi:10.1172/JCI2512.
Ghosh S, Hauser ER, Magnuson VL, Valle T, Ally DS, Karanjawala ZE, Rayman JB, Knapp JI, Musick A, Tannenbaum J, Te C, Eldridge W, Shapiro S, Musick T, Martin C, So A, Witt A, Harvan JB, Watanabe RM, Hagopian W, Eriksson J, Nylund SJ, Kohtamaki K, Tuomilehto-Wolf E, Boehnke M. A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. J Clin Invest. 1998 Aug 15;102(4):704–709.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

August 15, 1998

Volume

102

Issue

4

Start / End Page

704 / 709

Location

United States

Related Subject Headings

  • White People
  • Nuclear Family
  • Middle Aged
  • Male
  • Lod Score
  • Likelihood Functions
  • Immunology
  • Humans
  • Genotype
  • Genetic Markers