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BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.

Publication ,  Journal Article
Chamberlain, JS; Boehnke, M; Frank, TS; Kiousis, S; Xu, J; Guo, SW; Hauser, ER; Norum, RA; Helmbold, EA; Markel, DS
Published in: Am J Hum Genet
April 1993

Previous studies have demonstrated linkage between early-onset breast cancer and ovarian cancer and genetic markers on chromosome 17q21. These markers define the location of a gene (BRCA1) which appears to be inherited as an autosomal dominant susceptibility allele. We analyzed five families with multiple affected individuals for evidence of linkage to the BRCA1 region. Two of the five families appear to be linked to BRCA1. One apparently linked family contains critical recombinants, suggesting that the gene is proximal to the marker D17S579 (Mfd188). These findings are consistent with the maximum-likelihood position estimated by the Breast Cancer Linkage Consortium and with recombination events detected in other linked families. Linkage analysis was greatly aided by PCR-based analysis of paraffin-embedded normal breast tissue from deceased family members, demonstrating the feasibility and importance of this approach. One of the two families with evidence of linkage between breast cancer and genetic markers flanking BRCA1 represents the first such family of African-American descent to be reported in detail.

Duke Scholars

Published In

Am J Hum Genet

ISSN

0002-9297

Publication Date

April 1993

Volume

52

Issue

4

Start / End Page

792 / 798

Location

United States

Related Subject Headings

  • Proto-Oncogenes
  • Polymerase Chain Reaction
  • Pedigree
  • Ovarian Neoplasms
  • Neoplastic Syndromes, Hereditary
  • Molecular Sequence Data
  • Lod Score
  • Humans
  • Genetics & Heredity
  • Genetic Markers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chamberlain, J. S., Boehnke, M., Frank, T. S., Kiousis, S., Xu, J., Guo, S. W., … Markel, D. S. (1993). BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet, 52(4), 792–798.
Chamberlain, J. S., M. Boehnke, T. S. Frank, S. Kiousis, J. Xu, S. W. Guo, E. R. Hauser, R. A. Norum, E. A. Helmbold, and D. S. Markel. “BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.Am J Hum Genet 52, no. 4 (April 1993): 792–98.
Chamberlain JS, Boehnke M, Frank TS, Kiousis S, Xu J, Guo SW, et al. BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet. 1993 Apr;52(4):792–8.
Chamberlain, J. S., et al. “BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.Am J Hum Genet, vol. 52, no. 4, Apr. 1993, pp. 792–98.
Chamberlain JS, Boehnke M, Frank TS, Kiousis S, Xu J, Guo SW, Hauser ER, Norum RA, Helmbold EA, Markel DS. BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet. 1993 Apr;52(4):792–798.
Journal cover image

Published In

Am J Hum Genet

ISSN

0002-9297

Publication Date

April 1993

Volume

52

Issue

4

Start / End Page

792 / 798

Location

United States

Related Subject Headings

  • Proto-Oncogenes
  • Polymerase Chain Reaction
  • Pedigree
  • Ovarian Neoplasms
  • Neoplastic Syndromes, Hereditary
  • Molecular Sequence Data
  • Lod Score
  • Humans
  • Genetics & Heredity
  • Genetic Markers