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On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.

Publication ,  Journal Article
Cohn, JA; Alvares, AP; Kappas, A
Published in: The Journal of experimental medicine
June 1977

The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.

Duke Scholars

Published In

The Journal of experimental medicine

DOI

EISSN

1540-9538

ISSN

0022-1007

Publication Date

June 1977

Volume

145

Issue

6

Start / End Page

1607 / 1611

Related Subject Headings

  • Rats
  • NAD
  • Microsomes
  • Methylmercury Compounds
  • Methylcholanthrene
  • Male
  • Immunology
  • Dithionite
  • Cytochromes
  • Cytochrome P-450 Enzyme System
 

Citation

APA
Chicago
ICMJE
MLA
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Cohn, J. A., Alvares, A. P., & Kappas, A. (1977). On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of Experimental Medicine, 145(6), 1607–1611. https://doi.org/10.1084/jem.145.6.1607
Cohn, J. A., A. P. Alvares, and A. Kappas. “On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.The Journal of Experimental Medicine 145, no. 6 (June 1977): 1607–11. https://doi.org/10.1084/jem.145.6.1607.
Cohn JA, Alvares AP, Kappas A. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of experimental medicine. 1977 Jun;145(6):1607–11.
Cohn, J. A., et al. “On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.The Journal of Experimental Medicine, vol. 145, no. 6, June 1977, pp. 1607–11. Epmc, doi:10.1084/jem.145.6.1607.
Cohn JA, Alvares AP, Kappas A. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of experimental medicine. 1977 Jun;145(6):1607–1611.

Published In

The Journal of experimental medicine

DOI

EISSN

1540-9538

ISSN

0022-1007

Publication Date

June 1977

Volume

145

Issue

6

Start / End Page

1607 / 1611

Related Subject Headings

  • Rats
  • NAD
  • Microsomes
  • Methylmercury Compounds
  • Methylcholanthrene
  • Male
  • Immunology
  • Dithionite
  • Cytochromes
  • Cytochrome P-450 Enzyme System