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Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata.

Publication ,  Journal Article
Werling, LL; Nadler, JV
Published in: Brain Res
October 16, 1983

Two binding sites for L-[3H]glutamate were tentatively localized in rat fascia dentata by determining the effects of selective lesions on specific binding. Both destruction of dentate granule cells with colchicine and ablation of the ipsilateral entorhinal cortex markedly reduced radioligand binding to a quisqualate-sensitive site (GLU A), but only the entorhinal lesion significantly reduced binding to a site that is less sensitive to quisqualate (GLU B). These results suggest that GLU A binding sites are localized mainly on the dentate granule cells, whereas GLU B binding sites are localized, in part, on the perforant path fibers, but not on granule cells.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 16, 1983

Volume

276

Issue

2

Start / End Page

344 / 347

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Quisqualic Acid
  • Oxadiazoles
  • Neurology & Neurosurgery
  • Neural Pathways
  • Hippocampus
  • Glutamic Acid
  • Glutamates
  • Female
 

Citation

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Werling, L. L., & Nadler, J. V. (1983). Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata. Brain Res, 276(2), 344–347. https://doi.org/10.1016/0006-8993(83)90744-8
Werling, L. L., and J. V. Nadler. “Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata.Brain Res 276, no. 2 (October 16, 1983): 344–47. https://doi.org/10.1016/0006-8993(83)90744-8.
Werling, L. L., and J. V. Nadler. “Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata.Brain Res, vol. 276, no. 2, Oct. 1983, pp. 344–47. Pubmed, doi:10.1016/0006-8993(83)90744-8.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 16, 1983

Volume

276

Issue

2

Start / End Page

344 / 347

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Quisqualic Acid
  • Oxadiazoles
  • Neurology & Neurosurgery
  • Neural Pathways
  • Hippocampus
  • Glutamic Acid
  • Glutamates
  • Female