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Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product.

Publication ,  Journal Article
Gulley, ML; Nicholls, JM; Schneider, BG; Amin, MB; Ro, JY; Geradts, J
Published in: Am J Pathol
April 1998

The p16/MTS1 gene is altered by deletion, mutation, or hypermethylation in a wide variety of human cancers. As a result of deficient p16 protein, these cancers lack a critical mechanism for halting G1/S cell cycle progression. In the current study, 59 cases of nasopharyngeal carcinoma were evaluated for expression of the p16 tumor suppressor protein by immunohistochemical analysis of paraffin-embedded tissue. There was no detectable p16 in 38/59 cases (64%), which implies a very high rate of p16 inactivation in this type of cancer. On the other hand, the retinoblastoma gene product, which also regulates the G1 to S phase transition of the cell cycle, was consistently expressed in nasopharyngeal carcinomas by immunohistochemical analysis. These results implicate p16 inactivation but not Rb alteration in the stepwise progression of nasopharyngeal carcinogenesis.

Duke Scholars

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

April 1998

Volume

152

Issue

4

Start / End Page

865 / 869

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Retrospective Studies
  • Retinoblastoma Protein
  • RNA, Viral
  • Pathology
  • Nasopharyngeal Neoplasms
  • In Situ Hybridization
  • Immunohistochemistry
  • Humans
  • Herpesvirus 4, Human
 

Citation

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MLA
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Gulley, M. L., Nicholls, J. M., Schneider, B. G., Amin, M. B., Ro, J. Y., & Geradts, J. (1998). Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol, 152(4), 865–869.
Gulley, M. L., J. M. Nicholls, B. G. Schneider, M. B. Amin, J. Y. Ro, and J. Geradts. “Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product.Am J Pathol 152, no. 4 (April 1998): 865–69.
Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J. Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol. 1998 Apr;152(4):865–9.
Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J. Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol. 1998 Apr;152(4):865–869.
Journal cover image

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

April 1998

Volume

152

Issue

4

Start / End Page

865 / 869

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Retrospective Studies
  • Retinoblastoma Protein
  • RNA, Viral
  • Pathology
  • Nasopharyngeal Neoplasms
  • In Situ Hybridization
  • Immunohistochemistry
  • Humans
  • Herpesvirus 4, Human