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HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites.

Publication ,  Journal Article
Millikan, R; Eaton, A; Worley, K; Biscocho, L; Hodgson, E; Huang, W-Y; Geradts, J; Iacocca, M; Cowan, D; Conway, K; Dressler, L
Published in: Breast Cancer Res Treat
June 2003

BACKGROUND: Several recent epidemiologic studies examined the association between breast cancer risk and an inherited, single-nucleotide polymorphism in the HER2 gene, codon 655 G to A, which leads to an amino acid substitution of Ile to Val. Results of previous studies have been mixed, with most studies showing no association but some suggesting an association in younger women or women with a family history of breast cancer. METHODS: We conducted an association study of HER2 codon 655 genotype and breast cancer within the Carolina Breast Cancer study, a population-based, case-control study of in situ and invasive breast cancer in African American and white women in North Carolina. A total of 2015 cases and 1808 controls were genotyped. RESULTS: We observed no overall association between HER2 genotype and breast cancer. However, a modest positive association (OR = 2.3, 95% CI 1.0-5.3) was observed for Val/Val + Ile/Val versus Ile/Ile genotypes in women age 45 or younger with a family history of breast cancer. Val/Val homozygotes were more common among cases with in situ versus invasive disease (P = 0.002). Breast tumors from women with Val/Val genotype were more likely to exhibit HER2 overexpression, but the results were not statistically significant (P = 0.17). CONCLUSIONS: The HER2 codon 655 polymorphism may be one of many low-penetrant genes that make a minor contribution to breast cancer, particularly in subgroups of women. Additional large studies, as well as data pooling, will be needed to estimate the contribution of such genes to breast cancer risk.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

June 2003

Volume

79

Issue

3

Start / End Page

355 / 364

Location

Netherlands

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Point Mutation
  • Pedigree
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Invasiveness
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Millikan, R., Eaton, A., Worley, K., Biscocho, L., Hodgson, E., Huang, W.-Y., … Dressler, L. (2003). HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. Breast Cancer Res Treat, 79(3), 355–364. https://doi.org/10.1023/a:1024068525763
Millikan, Robert, Allison Eaton, Kendra Worley, Lorna Biscocho, Elizabeth Hodgson, Wen-Yi Huang, Joseph Geradts, et al. “HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites.Breast Cancer Res Treat 79, no. 3 (June 2003): 355–64. https://doi.org/10.1023/a:1024068525763.
Millikan R, Eaton A, Worley K, Biscocho L, Hodgson E, Huang W-Y, et al. HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. Breast Cancer Res Treat. 2003 Jun;79(3):355–64.
Millikan, Robert, et al. “HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites.Breast Cancer Res Treat, vol. 79, no. 3, June 2003, pp. 355–64. Pubmed, doi:10.1023/a:1024068525763.
Millikan R, Eaton A, Worley K, Biscocho L, Hodgson E, Huang W-Y, Geradts J, Iacocca M, Cowan D, Conway K, Dressler L. HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. Breast Cancer Res Treat. 2003 Jun;79(3):355–364.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

June 2003

Volume

79

Issue

3

Start / End Page

355 / 364

Location

Netherlands

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Point Mutation
  • Pedigree
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Invasiveness
  • Middle Aged