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V(D)J hypermutation and receptor revision: coloring outside the lines.

Publication ,  Journal Article
Kelsoe, G
Published in: Curr Opin Immunol
February 1999

At least three mechanisms increase potential genetic diversity in peripheral B lymphocytes: hypermutation, gene conversion and secondary V(D)J rearrangements. These diversifying activities were once believed to be strictly confined to the immunoglobulin loci and B cells. Recent experiments demonstrate that this is not the case. Hypermutation has now been shown to diversify the BCL-6 genes of germinal-center B cells. The role, if any, of these mutations in the immune response remains unknown but the notion that the hypermutation mechanism is targeted solely to immunoglobulin genes is no longer tenable. Peripheral T cells may also diversify their antigen receptors by the reactivation of RAG (recombination-activating gene)1 and RAG2 and secondary V(D)J rearrangements. These new findings suggest a remarkable genetic plasticity in subsets of antigen-reactive lymphocytes and may frame new questions of clonal selection and self tolerance.

Duke Scholars

Published In

Curr Opin Immunol

DOI

ISSN

0952-7915

Publication Date

February 1999

Volume

11

Issue

1

Start / End Page

70 / 75

Location

England

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Mutation
  • Immunology
  • Immunoglobulin Variable Region
  • Humans
  • Genes, Immunoglobulin
  • B-Lymphocytes
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Kelsoe, G. (1999). V(D)J hypermutation and receptor revision: coloring outside the lines. Curr Opin Immunol, 11(1), 70–75. https://doi.org/10.1016/s0952-7915(99)80013-2
Kelsoe, G. “V(D)J hypermutation and receptor revision: coloring outside the lines.Curr Opin Immunol 11, no. 1 (February 1999): 70–75. https://doi.org/10.1016/s0952-7915(99)80013-2.
Kelsoe G. V(D)J hypermutation and receptor revision: coloring outside the lines. Curr Opin Immunol. 1999 Feb;11(1):70–5.
Kelsoe, G. “V(D)J hypermutation and receptor revision: coloring outside the lines.Curr Opin Immunol, vol. 11, no. 1, Feb. 1999, pp. 70–75. Pubmed, doi:10.1016/s0952-7915(99)80013-2.
Kelsoe G. V(D)J hypermutation and receptor revision: coloring outside the lines. Curr Opin Immunol. 1999 Feb;11(1):70–75.
Journal cover image

Published In

Curr Opin Immunol

DOI

ISSN

0952-7915

Publication Date

February 1999

Volume

11

Issue

1

Start / End Page

70 / 75

Location

England

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Mutation
  • Immunology
  • Immunoglobulin Variable Region
  • Humans
  • Genes, Immunoglobulin
  • B-Lymphocytes
  • Animals
  • 3204 Immunology
  • 1107 Immunology