Skip to main content

Immunosenescence and germinal center reaction.

Publication ,  Journal Article
Zheng, B; Han, S; Takahashi, Y; Kelsoe, G
Published in: Immunol Rev
December 1997

Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self-reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged. While this reduction is likely the result of age-associated impairment in lymphocyte function (e.g. diminished response to costimulus, altered lymphokine production etc.), the reduction of germinal centers may itself make an important contribution to further immunological dysfunction.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

December 1997

Volume

160

Start / End Page

63 / 77

Location

England

Related Subject Headings

  • Time Factors
  • Mutation
  • Mice
  • Immunology
  • Humans
  • Germinal Center
  • Bone Marrow
  • Antibody Formation
  • Animals
  • Aging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zheng, B., Han, S., Takahashi, Y., & Kelsoe, G. (1997). Immunosenescence and germinal center reaction. Immunol Rev, 160, 63–77. https://doi.org/10.1111/j.1600-065x.1997.tb01028.x
Zheng, B., S. Han, Y. Takahashi, and G. Kelsoe. “Immunosenescence and germinal center reaction.Immunol Rev 160 (December 1997): 63–77. https://doi.org/10.1111/j.1600-065x.1997.tb01028.x.
Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997 Dec;160:63–77.
Zheng, B., et al. “Immunosenescence and germinal center reaction.Immunol Rev, vol. 160, Dec. 1997, pp. 63–77. Pubmed, doi:10.1111/j.1600-065x.1997.tb01028.x.
Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997 Dec;160:63–77.

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

December 1997

Volume

160

Start / End Page

63 / 77

Location

England

Related Subject Headings

  • Time Factors
  • Mutation
  • Mice
  • Immunology
  • Humans
  • Germinal Center
  • Bone Marrow
  • Antibody Formation
  • Animals
  • Aging