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Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.

Publication ,  Journal Article
Pao, W; Wen, L; Smith, AL; Gulbranson-Judge, A; Zheng, B; Kelsoe, G; MacLennan, IC; Owen, MJ; Hayday, AC
Published in: Curr Biol
October 1, 1996

BACKGROUND: gamma delta T cells, like alpha beta T cells, are components of all well-studied vertebrate immune systems. Yet, the contribution of gamma delta T cells to immune responses is poorly characterized. In particular, it has not been resolved whether gamma delta cells, independent of any other T cells, can help B cells produce immunoglobulin and form germinal centers, anatomical foci of specialized T cell-B cell collaboration. RESULTS: TCR beta-/- mice, which lack all T cells except gamma delta T cells, routinely displayed higher levels of antibody than fully T cell-deficient mice. Repeated parasitic infection of TCR beta-/- mice, but not of T cell-deficient mice, increased antibody levels and induced germinal centers that contained B cells and monoclonal gamma delta cells in close juxtaposition. However, antibody specificities were more commonly against self than against the challenging pathogen. gamma delta T cell-B cell help was not induced by repeated inoculation of TCR beta-/- mice with mycobacterial antigens. CONCLUSIONS: In the absence of any other T cells, gamma delta T cell-B cell collaboration can be significantly enhanced by repeated infection. However, the lack of obvious enrichment for antibodies against the challenging pathogen distinguishes gamma delta T cell help from alpha beta T cell help induced under analogous circumstances. The increased production of generalized antibodies may be particularly relevant to the development of autoimmunity, which commonly occurs in patients suffering from alpha beta T cell deficiencies, such as AIDS.

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Published In

Curr Biol

DOI

ISSN

0960-9822

Publication Date

October 1, 1996

Volume

6

Issue

10

Start / End Page

1317 / 1325

Location

England

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Receptors, Antigen, T-Cell, gamma-delta
  • Mice, Mutant Strains
  • Mice
  • Immunoglobulin G
  • Immunity, Cellular
  • Germinal Center
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Eimeria
  • Developmental Biology
 

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Pao, W., Wen, L., Smith, A. L., Gulbranson-Judge, A., Zheng, B., Kelsoe, G., … Hayday, A. C. (1996). Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol, 6(10), 1317–1325. https://doi.org/10.1016/s0960-9822(02)70718-5
Pao, W., L. Wen, A. L. Smith, A. Gulbranson-Judge, B. Zheng, G. Kelsoe, I. C. MacLennan, M. J. Owen, and A. C. Hayday. “Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.Curr Biol 6, no. 10 (October 1, 1996): 1317–25. https://doi.org/10.1016/s0960-9822(02)70718-5.
Pao W, Wen L, Smith AL, Gulbranson-Judge A, Zheng B, Kelsoe G, et al. Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol. 1996 Oct 1;6(10):1317–25.
Pao, W., et al. “Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.Curr Biol, vol. 6, no. 10, Oct. 1996, pp. 1317–25. Pubmed, doi:10.1016/s0960-9822(02)70718-5.
Pao W, Wen L, Smith AL, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan IC, Owen MJ, Hayday AC. Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol. 1996 Oct 1;6(10):1317–1325.
Journal cover image

Published In

Curr Biol

DOI

ISSN

0960-9822

Publication Date

October 1, 1996

Volume

6

Issue

10

Start / End Page

1317 / 1325

Location

England

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Receptors, Antigen, T-Cell, gamma-delta
  • Mice, Mutant Strains
  • Mice
  • Immunoglobulin G
  • Immunity, Cellular
  • Germinal Center
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Eimeria
  • Developmental Biology