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Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.

Publication ,  Journal Article
Kaushik, A; Reininger, L; Kelsoe, G; Jaton, JC; Bona, C
Published in: Eur J Immunol
March 1991

The contribution of VH11 gene family to the development of the primary B cell repertoire has been studied by analyzing 1.8 x 10(4) mitogen induced B lymphocyte colonies. The data demonstrate that VH11 family is predominantly expressed among neonatal splenic as well as adult peritoneal B cell colonies, both rich in Ly-1+ B cells. VH11 gene family expression among B splenocytes decreases during ontogeny and VH11 family pairs stochastically with different V kappa families among mitogen-activated neonatal B cell colonies, which are representative of an antigen unselected B cell repertoire. Thus, an increased VH11 expression among peritoneal and neonatal B cells points towards its biased expression among Ly-1+ B lymphocytes. The restricted V gene rearrangements and VH11-V kappa 9 pairing observed among anti-bromelain-treated mouse red blood cells autoantibodies are likely to be an outcome of both intrinsic gene recombination processes per se as well as selection by an autoantigen and/or local selective environmental factors.

Duke Scholars

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

March 1991

Volume

21

Issue

3

Start / End Page

827 / 830

Location

Germany

Related Subject Headings

  • Nucleic Acid Hybridization
  • Mitogens
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin Variable Region
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Genes, Immunoglobulin
  • Gene Expression
 

Citation

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Kaushik, A., Reininger, L., Kelsoe, G., Jaton, J. C., & Bona, C. (1991). Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. Eur J Immunol, 21(3), 827–830. https://doi.org/10.1002/eji.1830210344
Kaushik, A., L. Reininger, G. Kelsoe, J. C. Jaton, and C. Bona. “Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.Eur J Immunol 21, no. 3 (March 1991): 827–30. https://doi.org/10.1002/eji.1830210344.
Kaushik A, Reininger L, Kelsoe G, Jaton JC, Bona C. Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. Eur J Immunol. 1991 Mar;21(3):827–30.
Kaushik, A., et al. “Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.Eur J Immunol, vol. 21, no. 3, Mar. 1991, pp. 827–30. Pubmed, doi:10.1002/eji.1830210344.
Kaushik A, Reininger L, Kelsoe G, Jaton JC, Bona C. Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. Eur J Immunol. 1991 Mar;21(3):827–830.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

March 1991

Volume

21

Issue

3

Start / End Page

827 / 830

Location

Germany

Related Subject Headings

  • Nucleic Acid Hybridization
  • Mitogens
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin Variable Region
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Genes, Immunoglobulin
  • Gene Expression