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Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.

Publication ,  Journal Article
Ueda, Y; Yang, K; Foster, SJ; Kondo, M; Kelsoe, G
Published in: J Exp Med
January 5, 2004

Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive granulocytosis. Here, we demonstrate that inflammation, acting primarily through tumor necrosis factor alpha (TNFalpha), mobilizes BM lymphocytes. Mobilization reflects a reduced CXCL12 message and protein in BM and changes to the BM environment that prevents homing by cells from naive donors. The effects of TNFalpha are potentiated by interleukin 1 beta (IL-1beta), which acts primarily to expand the BM granulocyte compartment. Our observations indicate that inflammation induces lymphocyte mobilization by suppressing CXCL12 retention signals in BM, which, in turn, increases the ability of IL-1beta to expand the BM granulocyte compartment. Consistent with this idea, lymphocyte mobilization and a modest expansion of BM granulocyte numbers follow injections of pertussis toxin. We propose that TNFalpha and IL-1beta transiently specialize the BM to support acute granulocytic responses and consequently promote extramedullary lymphopoiesis.

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Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

January 5, 2004

Volume

199

Issue

1

Start / End Page

47 / 58

Location

United States

Related Subject Headings

  • Stromal Cells
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Inflammation
  • Immunology
  • Gene Expression Regulation
 

Citation

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Ueda, Y., Yang, K., Foster, S. J., Kondo, M., & Kelsoe, G. (2004). Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med, 199(1), 47–58. https://doi.org/10.1084/jem.20031104
Ueda, Yoshihiro, Kaiyong Yang, Sandra J. Foster, Motonari Kondo, and Garnett Kelsoe. “Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.J Exp Med 199, no. 1 (January 5, 2004): 47–58. https://doi.org/10.1084/jem.20031104.
Ueda Y, Yang K, Foster SJ, Kondo M, Kelsoe G. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med. 2004 Jan 5;199(1):47–58.
Ueda, Yoshihiro, et al. “Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.J Exp Med, vol. 199, no. 1, Jan. 2004, pp. 47–58. Pubmed, doi:10.1084/jem.20031104.
Ueda Y, Yang K, Foster SJ, Kondo M, Kelsoe G. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med. 2004 Jan 5;199(1):47–58.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

January 5, 2004

Volume

199

Issue

1

Start / End Page

47 / 58

Location

United States

Related Subject Headings

  • Stromal Cells
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Inflammation
  • Immunology
  • Gene Expression Regulation