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Murine V kappa gene expression does not follow the VH paradigm.

Publication ,  Journal Article
Kaushik, A; Schulze, DH; Bona, C; Kelsoe, G
Published in: J Exp Med
May 1, 1989

V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.

Duke Scholars

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

May 1, 1989

Volume

169

Issue

5

Start / End Page

1859 / 1864

Location

United States

Related Subject Headings

  • Nucleic Acid Hybridization
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin kappa-Chains
  • Immunoglobulin Variable Region
  • Immunoglobulin Heavy Chains
  • Genes, Immunoglobulin
  • Gene Expression Regulation
  • DNA Probes
 

Citation

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Kaushik, A., Schulze, D. H., Bona, C., & Kelsoe, G. (1989). Murine V kappa gene expression does not follow the VH paradigm. J Exp Med, 169(5), 1859–1864. https://doi.org/10.1084/jem.169.5.1859
Kaushik, A., D. H. Schulze, C. Bona, and G. Kelsoe. “Murine V kappa gene expression does not follow the VH paradigm.J Exp Med 169, no. 5 (May 1, 1989): 1859–64. https://doi.org/10.1084/jem.169.5.1859.
Kaushik A, Schulze DH, Bona C, Kelsoe G. Murine V kappa gene expression does not follow the VH paradigm. J Exp Med. 1989 May 1;169(5):1859–64.
Kaushik, A., et al. “Murine V kappa gene expression does not follow the VH paradigm.J Exp Med, vol. 169, no. 5, May 1989, pp. 1859–64. Pubmed, doi:10.1084/jem.169.5.1859.
Kaushik A, Schulze DH, Bona C, Kelsoe G. Murine V kappa gene expression does not follow the VH paradigm. J Exp Med. 1989 May 1;169(5):1859–1864.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

May 1, 1989

Volume

169

Issue

5

Start / End Page

1859 / 1864

Location

United States

Related Subject Headings

  • Nucleic Acid Hybridization
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin kappa-Chains
  • Immunoglobulin Variable Region
  • Immunoglobulin Heavy Chains
  • Genes, Immunoglobulin
  • Gene Expression Regulation
  • DNA Probes