Murine V kappa gene expression does not follow the VH paradigm.
Publication
, Journal Article
Kaushik, A; Schulze, DH; Bona, C; Kelsoe, G
Published in: J Exp Med
May 1, 1989
V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.
Duke Scholars
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
May 1, 1989
Volume
169
Issue
5
Start / End Page
1859 / 1864
Location
United States
Related Subject Headings
- Nucleic Acid Hybridization
- Mice, Inbred C57BL
- Mice
- Immunology
- Immunoglobulin kappa-Chains
- Immunoglobulin Variable Region
- Immunoglobulin Heavy Chains
- Genes, Immunoglobulin
- Gene Expression Regulation
- DNA Probes
Citation
APA
Chicago
ICMJE
MLA
NLM
Kaushik, A., Schulze, D. H., Bona, C., & Kelsoe, G. (1989). Murine V kappa gene expression does not follow the VH paradigm. J Exp Med, 169(5), 1859–1864. https://doi.org/10.1084/jem.169.5.1859
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
May 1, 1989
Volume
169
Issue
5
Start / End Page
1859 / 1864
Location
United States
Related Subject Headings
- Nucleic Acid Hybridization
- Mice, Inbred C57BL
- Mice
- Immunology
- Immunoglobulin kappa-Chains
- Immunoglobulin Variable Region
- Immunoglobulin Heavy Chains
- Genes, Immunoglobulin
- Gene Expression Regulation
- DNA Probes