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Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

Publication ,  Journal Article
Croix, DA; Ahearn, JM; Rosengard, AM; Han, S; Kelsoe, G; Ma, M; Carroll, MC
Published in: J Exp Med
April 1, 1996

Several lines of evidence indicate that antibody responses to T-dependent antigens require complement receptors expressed on either B lymphocytes or follicular dendritic cells. We have used RAG-2 deficient blastocyst complementation to create mice specifically lacking B cell complement receptors. Despite normal expression of complement receptor 1 (CR1[CD35]) and CR2 (CD21) on follicular dendritic cells, these mice have a profound defect in their capacity to mount a T-dependent antibody response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This suggests that CD21 and/or CD35 on B lymphocytes may be required for cellular activation, adsorptive endocytosis of antigen, recruitment to germinal centers, and/or protection from apoptosis during the humoral response to T-dependent antigens.

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Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

April 1, 1996

Volume

183

Issue

4

Start / End Page

1857 / 1864

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Spleen
  • Receptors, Complement 3d
  • Receptors, Complement 3b
  • Receptors, Complement
  • Proteins
  • Mutagenesis
  • Mice, Mutant Strains
  • Mice
  • Immunology
 

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Croix, D. A., Ahearn, J. M., Rosengard, A. M., Han, S., Kelsoe, G., Ma, M., & Carroll, M. C. (1996). Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med, 183(4), 1857–1864. https://doi.org/10.1084/jem.183.4.1857
Croix, D. A., J. M. Ahearn, A. M. Rosengard, S. Han, G. Kelsoe, M. Ma, and M. C. Carroll. “Antibody response to a T-dependent antigen requires B cell expression of complement receptors.J Exp Med 183, no. 4 (April 1, 1996): 1857–64. https://doi.org/10.1084/jem.183.4.1857.
Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, et al. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med. 1996 Apr 1;183(4):1857–64.
Croix, D. A., et al. “Antibody response to a T-dependent antigen requires B cell expression of complement receptors.J Exp Med, vol. 183, no. 4, Apr. 1996, pp. 1857–64. Pubmed, doi:10.1084/jem.183.4.1857.
Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med. 1996 Apr 1;183(4):1857–1864.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

April 1, 1996

Volume

183

Issue

4

Start / End Page

1857 / 1864

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Spleen
  • Receptors, Complement 3d
  • Receptors, Complement 3b
  • Receptors, Complement
  • Proteins
  • Mutagenesis
  • Mice, Mutant Strains
  • Mice
  • Immunology