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T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

Publication ,  Journal Article
Zheng, B; Han, S; Kelsoe, G
Published in: J Exp Med
September 1, 1996

After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.

Duke Scholars

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

September 1, 1996

Volume

184

Issue

3

Start / End Page

1083 / 1091

Location

United States

Related Subject Headings

  • Thy-1 Antigens
  • T-Lymphocytes, Helper-Inducer
  • Receptors, Antigen, T-Cell, alpha-beta
  • Phenotype
  • Molecular Sequence Data
  • Models, Biological
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Germinal Center
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zheng, B., Han, S., & Kelsoe, G. (1996). T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med, 184(3), 1083–1091. https://doi.org/10.1084/jem.184.3.1083
Zheng, B., S. Han, and G. Kelsoe. “T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.J Exp Med 184, no. 3 (September 1, 1996): 1083–91. https://doi.org/10.1084/jem.184.3.1083.
Zheng B, Han S, Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med. 1996 Sep 1;184(3):1083–91.
Zheng, B., et al. “T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.J Exp Med, vol. 184, no. 3, Sept. 1996, pp. 1083–91. Pubmed, doi:10.1084/jem.184.3.1083.
Zheng B, Han S, Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med. 1996 Sep 1;184(3):1083–1091.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

September 1, 1996

Volume

184

Issue

3

Start / End Page

1083 / 1091

Location

United States

Related Subject Headings

  • Thy-1 Antigens
  • T-Lymphocytes, Helper-Inducer
  • Receptors, Antigen, T-Cell, alpha-beta
  • Phenotype
  • Molecular Sequence Data
  • Models, Biological
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Germinal Center