T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
Publication
, Journal Article
Zheng, B; Han, S; Kelsoe, G
Published in: J Exp Med
September 1, 1996
After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.
Duke Scholars
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
September 1, 1996
Volume
184
Issue
3
Start / End Page
1083 / 1091
Location
United States
Related Subject Headings
- Thy-1 Antigens
- T-Lymphocytes, Helper-Inducer
- Receptors, Antigen, T-Cell, alpha-beta
- Phenotype
- Molecular Sequence Data
- Models, Biological
- Mice, Inbred C57BL
- Mice
- Immunology
- Germinal Center
Citation
APA
Chicago
ICMJE
MLA
NLM
Zheng, B., Han, S., & Kelsoe, G. (1996). T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med, 184(3), 1083–1091. https://doi.org/10.1084/jem.184.3.1083
Zheng, B., S. Han, and G. Kelsoe. “T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.” J Exp Med 184, no. 3 (September 1, 1996): 1083–91. https://doi.org/10.1084/jem.184.3.1083.
Zheng B, Han S, Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med. 1996 Sep 1;184(3):1083–91.
Zheng, B., et al. “T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.” J Exp Med, vol. 184, no. 3, Sept. 1996, pp. 1083–91. Pubmed, doi:10.1084/jem.184.3.1083.
Zheng B, Han S, Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med. 1996 Sep 1;184(3):1083–1091.
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
September 1, 1996
Volume
184
Issue
3
Start / End Page
1083 / 1091
Location
United States
Related Subject Headings
- Thy-1 Antigens
- T-Lymphocytes, Helper-Inducer
- Receptors, Antigen, T-Cell, alpha-beta
- Phenotype
- Molecular Sequence Data
- Models, Biological
- Mice, Inbred C57BL
- Mice
- Immunology
- Germinal Center