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Spontaneous formation of germinal centers in autoimmune mice.

Publication ,  Journal Article
Luzina, IG; Atamas, SP; Storrer, CE; daSilva, LC; Kelsoe, G; Papadimitriou, JC; Handwerger, BS
Published in: J Leukoc Biol
October 2001

The mechanisms of autoantibody production are not well understood. Germinal centers (GC) may be important sites of immune disregulation in autoimmune diseases. In this study, we document the presence of spontaneous GC formation in the spleens of several autoimmune mouse strains that spontaneously develop autoimmune Type I diabetes and a lupus-like disease. In contrast, mouse strains that do not develop lupus did not exhibit spontaneous formation of GC. In all of the autoimmune strains studied, GC were present at 1-2 months of age, a time that closely parallels the appearance of autoantibodies. Like the GC that develop after purposeful immunization, GC in autoimmune mice contained B220(+), PNA(+), and GL-7(+) B cells, and FDC-M1(+) follicular dendritic cells. In addition, spontaneously formed GC in autoimmunity and those caused by immunization were abrogated in a similar way by a short-term treatment with anti-CD40 ligand antibody. These data indicate that spontaneously forming GC in autoimmunity are similar to those appearing after purposeful immunization.

Duke Scholars

Published In

J Leukoc Biol

ISSN

0741-5400

Publication Date

October 2001

Volume

70

Issue

4

Start / End Page

578 / 584

Location

England

Related Subject Headings

  • Spleen
  • Mice, Inbred NOD
  • Mice
  • Lupus Erythematosus, Systemic
  • Kinetics
  • Immunophenotyping
  • Immunology
  • Immunohistochemistry
  • Germinal Center
  • Diabetes Mellitus, Type 1
 

Citation

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Luzina, I. G., Atamas, S. P., Storrer, C. E., daSilva, L. C., Kelsoe, G., Papadimitriou, J. C., & Handwerger, B. S. (2001). Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol, 70(4), 578–584.
Luzina, I. G., S. P. Atamas, C. E. Storrer, L. C. daSilva, G. Kelsoe, J. C. Papadimitriou, and B. S. Handwerger. “Spontaneous formation of germinal centers in autoimmune mice.J Leukoc Biol 70, no. 4 (October 2001): 578–84.
Luzina IG, Atamas SP, Storrer CE, daSilva LC, Kelsoe G, Papadimitriou JC, et al. Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol. 2001 Oct;70(4):578–84.
Luzina, I. G., et al. “Spontaneous formation of germinal centers in autoimmune mice.J Leukoc Biol, vol. 70, no. 4, Oct. 2001, pp. 578–84.
Luzina IG, Atamas SP, Storrer CE, daSilva LC, Kelsoe G, Papadimitriou JC, Handwerger BS. Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol. 2001 Oct;70(4):578–584.

Published In

J Leukoc Biol

ISSN

0741-5400

Publication Date

October 2001

Volume

70

Issue

4

Start / End Page

578 / 584

Location

England

Related Subject Headings

  • Spleen
  • Mice, Inbred NOD
  • Mice
  • Lupus Erythematosus, Systemic
  • Kinetics
  • Immunophenotyping
  • Immunology
  • Immunohistochemistry
  • Germinal Center
  • Diabetes Mellitus, Type 1