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Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.

Publication ,  Journal Article
Han, S; Zheng, B; Schatz, DG; Spanopoulou, E; Kelsoe, G
Published in: Science
December 20, 1996

The products of the Rag1 and Rag2 genes drive genomic V(D)J rearrangements that assemble functional immunoglobulin and T cell antigen receptor genes. Expression of the Rag genes has been thought to be limited to developmentally immature lymphocyte populations that in normal adult animals are primarily restricted to the bone marrow and thymus. Abundant RAG1 and RAG2 protein and messenger RNA was detected in the activated B cells that populate murine splenic and Peyer's patch germinal centers. Germinal center B cells thus share fundamental characteristics of immature lymphocytes, raising the possibility that antigen-dependent secondary V(D)J rearrangements modify the peripheral antibody repertoire.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 20, 1996

Volume

274

Issue

5295

Start / End Page

2094 / 2097

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • Proteins
  • Protein Biosynthesis
  • Polymerase Chain Reaction
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Immunoglobulin Class Switching
  • Immunization
  • Homeodomain Proteins
 

Citation

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Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E., & Kelsoe, G. (1996). Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science, 274(5295), 2094–2097. https://doi.org/10.1126/science.274.5295.2094
Han, S., B. Zheng, D. G. Schatz, E. Spanopoulou, and G. Kelsoe. “Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.Science 274, no. 5295 (December 20, 1996): 2094–97. https://doi.org/10.1126/science.274.5295.2094.
Han S, Zheng B, Schatz DG, Spanopoulou E, Kelsoe G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science. 1996 Dec 20;274(5295):2094–7.
Han, S., et al. “Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.Science, vol. 274, no. 5295, Dec. 1996, pp. 2094–97. Pubmed, doi:10.1126/science.274.5295.2094.
Han S, Zheng B, Schatz DG, Spanopoulou E, Kelsoe G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science. 1996 Dec 20;274(5295):2094–2097.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 20, 1996

Volume

274

Issue

5295

Start / End Page

2094 / 2097

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • Proteins
  • Protein Biosynthesis
  • Polymerase Chain Reaction
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Immunoglobulin Class Switching
  • Immunization
  • Homeodomain Proteins