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T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.

Publication ,  Journal Article
Ueda, Y; Liao, D; Yang, K; Patel, A; Kelsoe, G
Published in: J Immunol
March 15, 2007

Inflammation elicits a splenic lymphopoiesis of unknown physiologic significance but one that juxtaposes developing B cells and exogenous Ag. We show that immature and transitional 1 (immature/T1) B cells constitutively express activation-induced cytidine deaminase and B lymphocyte-induced maturation protein 1 in amounts that support accelerated plasmacytic differentiation and limited class-switch recombination. In vivo, activation of immature/T1 B cells by TLR ligands or bacterial vaccine rapidly induces T1 cells to divide, proliferate, and secrete IgM, IgG, or IgA Ab; in vitro, proliferation and differentiation are substantially enhanced by B cell-activating factor. We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for innate Ab responses to microbial pathogens.

Duke Scholars

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Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

March 15, 2007

Volume

178

Issue

6

Start / End Page

3593 / 3601

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Spleen
  • Plasma Cells
  • Mice, Nude
  • Mice, Knockout
  • Mice
  • Lymphopoiesis
  • Immunology
  • Immunoglobulins
  • Immunoglobulin Class Switching
 

Citation

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Ueda, Y., Liao, D., Yang, K., Patel, A., & Kelsoe, G. (2007). T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J Immunol, 178(6), 3593–3601. https://doi.org/10.4049/jimmunol.178.6.3593
Ueda, Yoshihiro, Dongmei Liao, Kaiyong Yang, Anjali Patel, and Garnett Kelsoe. “T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.J Immunol 178, no. 6 (March 15, 2007): 3593–3601. https://doi.org/10.4049/jimmunol.178.6.3593.
Ueda, Yoshihiro, et al. “T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.J Immunol, vol. 178, no. 6, Mar. 2007, pp. 3593–601. Pubmed, doi:10.4049/jimmunol.178.6.3593.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

March 15, 2007

Volume

178

Issue

6

Start / End Page

3593 / 3601

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Spleen
  • Plasma Cells
  • Mice, Nude
  • Mice, Knockout
  • Mice
  • Lymphopoiesis
  • Immunology
  • Immunoglobulins
  • Immunoglobulin Class Switching