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Absence of detectable pharmacological effects after oral administration of isoxsuprine.

Publication ,  Journal Article
Harkins, JD; Mundy, GD; Stanley, S; Woods, WE; Sams, RA; Richardson, DR; Grambow, SC; Tobin, T
Published in: Equine Vet J
July 1998

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

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Published In

Equine Vet J

DOI

ISSN

0425-1644

Publication Date

July 1998

Volume

30

Issue

4

Start / End Page

294 / 299

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Vasodilator Agents
  • Sweating
  • Skin Temperature
  • Skin
  • Respiration
  • Regional Blood Flow
  • Powders
  • Muscle Tonus
  • Motor Activity
 

Citation

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Harkins, J. D., Mundy, G. D., Stanley, S., Woods, W. E., Sams, R. A., Richardson, D. R., … Tobin, T. (1998). Absence of detectable pharmacological effects after oral administration of isoxsuprine. Equine Vet J, 30(4), 294–299. https://doi.org/10.1111/j.2042-3306.1998.tb04100.x
Harkins, J. D., G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, and T. Tobin. “Absence of detectable pharmacological effects after oral administration of isoxsuprine.Equine Vet J 30, no. 4 (July 1998): 294–99. https://doi.org/10.1111/j.2042-3306.1998.tb04100.x.
Harkins JD, Mundy GD, Stanley S, Woods WE, Sams RA, Richardson DR, et al. Absence of detectable pharmacological effects after oral administration of isoxsuprine. Equine Vet J. 1998 Jul;30(4):294–9.
Harkins, J. D., et al. “Absence of detectable pharmacological effects after oral administration of isoxsuprine.Equine Vet J, vol. 30, no. 4, July 1998, pp. 294–99. Pubmed, doi:10.1111/j.2042-3306.1998.tb04100.x.
Harkins JD, Mundy GD, Stanley S, Woods WE, Sams RA, Richardson DR, Grambow SC, Tobin T. Absence of detectable pharmacological effects after oral administration of isoxsuprine. Equine Vet J. 1998 Jul;30(4):294–299.
Journal cover image

Published In

Equine Vet J

DOI

ISSN

0425-1644

Publication Date

July 1998

Volume

30

Issue

4

Start / End Page

294 / 299

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Vasodilator Agents
  • Sweating
  • Skin Temperature
  • Skin
  • Respiration
  • Regional Blood Flow
  • Powders
  • Muscle Tonus
  • Motor Activity