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Telomere shortening in cultured autografts of patients with burns.

Publication ,  Journal Article
Counter, CM; Press, W; Compton, CC
Published in: Lancet
April 19, 2003

In extensive third-degree burns, donor sites for conventional split thickness skin grafts are limited. In such cases, cultured epithelial (keratinocyte) grafts are prepared from small samples of the patient's own skin and expanded in tissue culture, a process that may incur very many cell divisions. Telomeres shorten with each cell division, and are markers of cellular proliferative history. We therefore measured telomere length in healed cultured epithelial autografts from four patients with burns, and noted that their telomeres were shorter than those in non-cultured skin from the same individuals, and than those in skin of healthy donors older than 80 years. Such great loss of telomeric DNA suggests that engrafted cells might have a shortened lifespan, which could have negative repercussions on the long-term viability of these grafts.

Duke Scholars

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 19, 2003

Volume

361

Issue

9366

Start / End Page

1345 / 1346

Location

England

Related Subject Headings

  • Wound Healing
  • Ultrasonography
  • Tissue Engineering
  • Telomere
  • Skin Transplantation
  • Reference Values
  • Prognosis
  • Male
  • Humans
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
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Counter, C. M., Press, W., & Compton, C. C. (2003). Telomere shortening in cultured autografts of patients with burns. Lancet, 361(9366), 1345–1346. https://doi.org/10.1016/S0140-6736(03)13042-5
Counter, Christopher M., William Press, and Carolyn C. Compton. “Telomere shortening in cultured autografts of patients with burns.Lancet 361, no. 9366 (April 19, 2003): 1345–46. https://doi.org/10.1016/S0140-6736(03)13042-5.
Counter CM, Press W, Compton CC. Telomere shortening in cultured autografts of patients with burns. Lancet. 2003 Apr 19;361(9366):1345–6.
Counter, Christopher M., et al. “Telomere shortening in cultured autografts of patients with burns.Lancet, vol. 361, no. 9366, Apr. 2003, pp. 1345–46. Pubmed, doi:10.1016/S0140-6736(03)13042-5.
Counter CM, Press W, Compton CC. Telomere shortening in cultured autografts of patients with burns. Lancet. 2003 Apr 19;361(9366):1345–1346.
Journal cover image

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 19, 2003

Volume

361

Issue

9366

Start / End Page

1345 / 1346

Location

England

Related Subject Headings

  • Wound Healing
  • Ultrasonography
  • Tissue Engineering
  • Telomere
  • Skin Transplantation
  • Reference Values
  • Prognosis
  • Male
  • Humans
  • Graft Survival