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Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy.

Publication ,  Journal Article
Renick, SE; Seidler, FJ; McCook, EC; Slotkin, TA
Published in: Pediatr Res
March 1997

Neurotransmitters are thought to influence cell development in their target tissues. In the current study, neonatal rats were given 6-hydroxydopamine to produce permanent sympathetic denervation, and the effects on cardiac and hepatic DNA and protein synthesis were assessed. Lesioned animals showed deficits in cardiac DNA synthesis over the first 8 d postpartum, a period in which sympathetic innervation is sparse and synaptic norepinephrine concentrations are low; the effect of lesioning was also evident for protein synthesis. Subsequently, DNA synthesis in control animals declined precipitously during the second to third postnatal week, the phase associated with ingrowth of the majority of sympathetic terminals and sympathetic hyperactivity. Neonatal lesioning delayed the ontogenetic decline in DNA synthesis: this effect was not shared by protein synthesis. In the liver, a tissue whose cells, unlike the heart, maintain the ability to divide into adulthood, there was no effect of 6-hydroxydopamine on DNA synthesis and only minor changes in protein synthesis. These results suggest that neural input provides two distinct trophic signals to the developing heart: an early promotion of cell replication associated with low levels of stimulation, and a subsequent promotion of the switchover from cell replication, to cell differentiation and enlargement, associated with high levels of stimulation. In light of the precipitous rise in circulating catecholamines at parturition, and of the subsequent development of sympathetic innervation, catecholamines are likely to play a trophic role in the establishment of the proper pattern of cardiac cell development.

Duke Scholars

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

March 1997

Volume

41

Issue

3

Start / End Page

359 / 363

Location

United States

Related Subject Headings

  • Sympatholytics
  • Sympathetic Nervous System
  • Sympathectomy, Chemical
  • Rats, Sprague-Dawley
  • Rats
  • Protein Biosynthesis
  • Pediatrics
  • Oxidopamine
  • Organ Specificity
  • Norepinephrine
 

Citation

APA
Chicago
ICMJE
MLA
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Renick, S. E., Seidler, F. J., McCook, E. C., & Slotkin, T. A. (1997). Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy. Pediatr Res, 41(3), 359–363. https://doi.org/10.1203/00006450-199703000-00009
Renick, S. E., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy.Pediatr Res 41, no. 3 (March 1997): 359–63. https://doi.org/10.1203/00006450-199703000-00009.
Renick SE, Seidler FJ, McCook EC, Slotkin TA. Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy. Pediatr Res. 1997 Mar;41(3):359–63.
Renick, S. E., et al. “Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy.Pediatr Res, vol. 41, no. 3, Mar. 1997, pp. 359–63. Pubmed, doi:10.1203/00006450-199703000-00009.
Renick SE, Seidler FJ, McCook EC, Slotkin TA. Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy. Pediatr Res. 1997 Mar;41(3):359–363.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

March 1997

Volume

41

Issue

3

Start / End Page

359 / 363

Location

United States

Related Subject Headings

  • Sympatholytics
  • Sympathetic Nervous System
  • Sympathectomy, Chemical
  • Rats, Sprague-Dawley
  • Rats
  • Protein Biosynthesis
  • Pediatrics
  • Oxidopamine
  • Organ Specificity
  • Norepinephrine