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Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain.

Publication ,  Journal Article
Duncan, CP; Seidler, FJ; Lappi, SE; Slotkin, TA
Published in: Brain Res Dev Brain Res
August 1, 1990

To examine how catecholamines influence cell replication in the developing brain, we examined regional [3H]thymidine incorporation into DNA after acute challenge with an alpha-adrenergic blocking agent (phenoxybenzamine) or a beta-blocker (propranolol). Phenoxybenzamine inhibited DNA synthesis in 1-day-old rat pups but the effect was less pronounced at 8 days; regional differences corresponded to transient expression of alpha-receptors and their subsequent maturational decline. Propranolol given at 1 day of age exerted a regionally selective, promotional effect on DNA synthesis; in contrast, at 8 days, propranolol inhibited DNA synthesis in all brain regions. Propranolol, but not phenoxybenzamine, also exacerbated the reduction in DNA synthesis caused by neonatal hypoxia, and again the effect was limited to the 1-day-old group. These results indicate that catecholamines exert a dual action on DNA synthesis; the effects are dependent upon maturational profiles of specific receptor populations which are either transiently expressed or which couple to cell replication only during a critical period.

Duke Scholars

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

August 1, 1990

Volume

55

Issue

1

Start / End Page

29 / 33

Location

Netherlands

Related Subject Headings

  • Thymidine
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Phenoxybenzamine
  • Oxygen
  • Neurology & Neurosurgery
  • Hypoxia, Brain
  • DNA Replication
 

Citation

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MLA
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Duncan, C. P., Seidler, F. J., Lappi, S. E., & Slotkin, T. A. (1990). Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. Brain Res Dev Brain Res, 55(1), 29–33. https://doi.org/10.1016/0165-3806(90)90102-5
Duncan, C. P., F. J. Seidler, S. E. Lappi, and T. A. Slotkin. “Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain.Brain Res Dev Brain Res 55, no. 1 (August 1, 1990): 29–33. https://doi.org/10.1016/0165-3806(90)90102-5.
Duncan CP, Seidler FJ, Lappi SE, Slotkin TA. Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. Brain Res Dev Brain Res. 1990 Aug 1;55(1):29–33.
Duncan, C. P., et al. “Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain.Brain Res Dev Brain Res, vol. 55, no. 1, Aug. 1990, pp. 29–33. Pubmed, doi:10.1016/0165-3806(90)90102-5.
Duncan CP, Seidler FJ, Lappi SE, Slotkin TA. Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. Brain Res Dev Brain Res. 1990 Aug 1;55(1):29–33.
Journal cover image

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

August 1, 1990

Volume

55

Issue

1

Start / End Page

29 / 33

Location

Netherlands

Related Subject Headings

  • Thymidine
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Phenoxybenzamine
  • Oxygen
  • Neurology & Neurosurgery
  • Hypoxia, Brain
  • DNA Replication