Skip to main content

Neonatal central catecholaminergic lesions with intracisternal 6-hydroxydopamine: effects on development of presynaptic and postsynaptic components of peripheral sympathetic pathways and on the ornithine decarboxylase/polyamine system in heart, lung and kidney.

Publication ,  Journal Article
Slotkin, TA; Seidler, FJ; Haim, K; Cameron, AM; Antolick, L; Lau, C
Published in: J Pharmacol Exp Ther
December 1988

Peripheral sympathetic neurons are thought to provide trophic regulatory signals for development of adrenergic target tissues. In the current study, we destroyed central catecholaminergic pathways in the neonatal rat by intracisternal administration of 6-hydroxydopamine, which compromises sympathetic tone without ablating peripheral nerve terminals. Measurements of norepinephrine levels and turnover confirmed the effectiveness of the treatment in projections to heart, lung and kidney. The impairment of sympathetic tone was associated with a deficit in cardiac beta adrenergic receptor binding capabilities; in contrast, binding sites in the lung were unaffected and renal receptors were up-regulated. Similarly, intracisternal administration of 6-hydroxydopamine produced tissue-selective alterations in ornithine decarboxylase activity and levels of the polyamines. These results support the view that neural activity exerts an influence on the biochemical development of sympathetic target tissues; however, other trophic factors may derive from the presence of intact nerve terminals themselves, as distinct from activity.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

December 1988

Volume

247

Issue

3

Start / End Page

975 / 982

Location

United States

Related Subject Headings

  • Synapses
  • Sympathetic Nervous System
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pharmacology & Pharmacy
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Myocardium
 

Citation

APA
Chicago
ICMJE
MLA
NLM

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

December 1988

Volume

247

Issue

3

Start / End Page

975 / 982

Location

United States

Related Subject Headings

  • Synapses
  • Sympathetic Nervous System
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pharmacology & Pharmacy
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Myocardium