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Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.

Publication ,  Journal Article
Slotkin, TA; Weigel, SJ; Seidler, FJ; Whitmore, WL
Published in: Toxicol Lett
December 1982

The pattern of development of polyamine levels in hearts of preweanling rats whose mothers received methadone indicated initial deficits in both spermidine and spermine followed by rebound elevations, a pattern consistent with delayed cellular development. Since polyamines are thought to play important roles in nucleic acid and protein synthesis during cellular maturation, these alterations may participate in the retardation of tissue growth seen in the perinatal opiate syndrome.

Duke Scholars

Published In

Toxicol Lett

DOI

ISSN

0378-4274

Publication Date

December 1982

Volume

14

Issue

3-4

Start / End Page

131 / 135

Location

Netherlands

Related Subject Headings

  • Toxicology
  • Spermine
  • Spermidine
  • Rats, Inbred Strains
  • Rats
  • Putrescine
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Polyamines
  • Ornithine Decarboxylase
 

Citation

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Slotkin, T. A., Weigel, S. J., Seidler, F. J., & Whitmore, W. L. (1982). Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. Toxicol Lett, 14(3–4), 131–135. https://doi.org/10.1016/0378-4274(82)90041-8
Slotkin, T. A., S. J. Weigel, F. J. Seidler, and W. L. Whitmore. “Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.Toxicol Lett 14, no. 3–4 (December 1982): 131–35. https://doi.org/10.1016/0378-4274(82)90041-8.
Slotkin, T. A., et al. “Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.Toxicol Lett, vol. 14, no. 3–4, Dec. 1982, pp. 131–35. Pubmed, doi:10.1016/0378-4274(82)90041-8.
Journal cover image

Published In

Toxicol Lett

DOI

ISSN

0378-4274

Publication Date

December 1982

Volume

14

Issue

3-4

Start / End Page

131 / 135

Location

Netherlands

Related Subject Headings

  • Toxicology
  • Spermine
  • Spermidine
  • Rats, Inbred Strains
  • Rats
  • Putrescine
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Polyamines
  • Ornithine Decarboxylase