Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Publication
, Journal Article
Slotkin, TA; Weigel, SJ; Seidler, FJ; Whitmore, WL
Published in: Toxicol Lett
December 1982
The pattern of development of polyamine levels in hearts of preweanling rats whose mothers received methadone indicated initial deficits in both spermidine and spermine followed by rebound elevations, a pattern consistent with delayed cellular development. Since polyamines are thought to play important roles in nucleic acid and protein synthesis during cellular maturation, these alterations may participate in the retardation of tissue growth seen in the perinatal opiate syndrome.
Duke Scholars
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
December 1982
Volume
14
Issue
3-4
Start / End Page
131 / 135
Location
Netherlands
Related Subject Headings
- Toxicology
- Spermine
- Spermidine
- Rats, Inbred Strains
- Rats
- Putrescine
- Prenatal Exposure Delayed Effects
- Pregnancy
- Polyamines
- Ornithine Decarboxylase
Citation
APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., Weigel, S. J., Seidler, F. J., & Whitmore, W. L. (1982). Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. Toxicol Lett, 14(3–4), 131–135. https://doi.org/10.1016/0378-4274(82)90041-8
Slotkin, T. A., S. J. Weigel, F. J. Seidler, and W. L. Whitmore. “Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.” Toxicol Lett 14, no. 3–4 (December 1982): 131–35. https://doi.org/10.1016/0378-4274(82)90041-8.
Slotkin TA, Weigel SJ, Seidler FJ, Whitmore WL. Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. Toxicol Lett. 1982 Dec;14(3–4):131–5.
Slotkin, T. A., et al. “Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.” Toxicol Lett, vol. 14, no. 3–4, Dec. 1982, pp. 131–35. Pubmed, doi:10.1016/0378-4274(82)90041-8.
Slotkin TA, Weigel SJ, Seidler FJ, Whitmore WL. Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. Toxicol Lett. 1982 Dec;14(3–4):131–135.
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
December 1982
Volume
14
Issue
3-4
Start / End Page
131 / 135
Location
Netherlands
Related Subject Headings
- Toxicology
- Spermine
- Spermidine
- Rats, Inbred Strains
- Rats
- Putrescine
- Prenatal Exposure Delayed Effects
- Pregnancy
- Polyamines
- Ornithine Decarboxylase