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Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion?

Publication ,  Journal Article
Seidler, FJ; Slotkin, TA
Published in: Brain Res
August 1986

When subjected to stress, neonatal rats secrete adrenal catecholamines by a mechanism which does not require nerve stimulation. To test whether the non-neurogenic secretory mechanism involves exocytosis, we examined the effects of hypoxia (a non-neurogenic stimulus) and nicotine (a stimulus which simulates neurogenic input) on catecholamine levels and on the uptake of [3H]epinephrine into chromaffin granules. Hypoxia- and nicotine-induced depletion of catecholamines were both accompanied by a reduction in uptake, indicating a loss of granule integrity which is characteristic of exocytosis. Although a significant proportion of adrenal catecholamines was found to be extragranular, only the granular pool was involved in the secretory response.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 1986

Volume

393

Issue

2

Start / End Page

274 / 277

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • Male
  • Hypoxia
  • Exocytosis
  • Diffusion
  • Chromaffin Granules
  • Catecholamines
 

Citation

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Seidler, F. J., & Slotkin, T. A. (1986). Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion? Brain Res, 393(2), 274–277. https://doi.org/10.1016/0165-3806(86)90031-3
Seidler, F. J., and T. A. Slotkin. “Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion?Brain Res 393, no. 2 (August 1986): 274–77. https://doi.org/10.1016/0165-3806(86)90031-3.
Seidler FJ, Slotkin TA. Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion? Brain Res. 1986 Aug;393(2):274–7.
Seidler, F. J., and T. A. Slotkin. “Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion?Brain Res, vol. 393, no. 2, Aug. 1986, pp. 274–77. Pubmed, doi:10.1016/0165-3806(86)90031-3.
Seidler FJ, Slotkin TA. Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion? Brain Res. 1986 Aug;393(2):274–277.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 1986

Volume

393

Issue

2

Start / End Page

274 / 277

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • Male
  • Hypoxia
  • Exocytosis
  • Diffusion
  • Chromaffin Granules
  • Catecholamines