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Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover.

Publication ,  Journal Article
Seidler, FJ; Slotkin, TA
Published in: Brain Res Bull
February 1990

Neonatal rats were exposed to 2 hr of hypoxia (7% O2) on the day after birth and examined for effects on development of noradrenergic and dopaminergic systems. Measurements were made of transmitter levels and turnover, the latter a biochemical index of neuronal activity. Hypoxia had a regionally selective effect, characterized by a long-lasting increase in turnover of norepinephrine and dopamine in midbrain and brainstem, with little or no effect in cerebral cortex or cerebellum. The effects of hypoxia were exacerbated when peripheral alpha-adrenergic receptors were blocked with phenoxybenzamine during the hypoxic exposure; in this case, the same abnormalities were then seen in the cerebral cortex as well. Thus, the release of peripheral catecholamines during the hypoxic insult, and their actions at alpha-adrenergic receptors, may play a role in protecting the neonatal nervous system from hypoxia-induced alterations.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

February 1990

Volume

24

Issue

2

Start / End Page

157 / 161

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha
  • Phenoxybenzamine
  • Peripheral Nerves
  • Neurology & Neurosurgery
  • Hypoxia, Brain
  • Catecholamines
  • Animals, Newborn
  • Animals
  • Age Factors
  • Adrenergic Fibers
 

Citation

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Seidler, F. J., & Slotkin, T. A. (1990). Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover. Brain Res Bull, 24(2), 157–161. https://doi.org/10.1016/0361-9230(90)90200-j
Seidler, F. J., and T. A. Slotkin. “Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover.Brain Res Bull 24, no. 2 (February 1990): 157–61. https://doi.org/10.1016/0361-9230(90)90200-j.
Seidler, F. J., and T. A. Slotkin. “Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover.Brain Res Bull, vol. 24, no. 2, Feb. 1990, pp. 157–61. Pubmed, doi:10.1016/0361-9230(90)90200-j.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

February 1990

Volume

24

Issue

2

Start / End Page

157 / 161

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha
  • Phenoxybenzamine
  • Peripheral Nerves
  • Neurology & Neurosurgery
  • Hypoxia, Brain
  • Catecholamines
  • Animals, Newborn
  • Animals
  • Age Factors
  • Adrenergic Fibers