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Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.

Publication ,  Journal Article
Slotkin, TA; Seidler, FJ; Crain, BJ; Bell, JM; Bissette, G; Nemeroff, CB
Published in: Proc Natl Acad Sci U S A
April 1990

Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function. Consistent with loss of cholinergic projections, cerebral cortical areas involved in AD exhibited decreased choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6) activity. However, remaining nerve terminals in these regions displayed marked up-regulation of synaptosomal high affinity [3H]choline uptake, a result indicative of relative cholinergic hyperactivity. As choline uptake is also rate-limiting in acetylcholine biosynthesis, these findings have implications for both therapy and identification of causes contributing to neuronal death in AD.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 1990

Volume

87

Issue

7

Start / End Page

2452 / 2455

Location

United States

Related Subject Headings

  • Synaptosomes
  • Synapses
  • Organ Specificity
  • Humans
  • Choline O-Acetyltransferase
  • Choline
  • Brain
  • Autopsy
  • Alzheimer Disease
 

Citation

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Slotkin, T. A., Seidler, F. J., Crain, B. J., Bell, J. M., Bissette, G., & Nemeroff, C. B. (1990). Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. Proc Natl Acad Sci U S A, 87(7), 2452–2455. https://doi.org/10.1073/pnas.87.7.2452
Slotkin, T. A., F. J. Seidler, B. J. Crain, J. M. Bell, G. Bissette, and C. B. Nemeroff. “Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.Proc Natl Acad Sci U S A 87, no. 7 (April 1990): 2452–55. https://doi.org/10.1073/pnas.87.7.2452.
Slotkin TA, Seidler FJ, Crain BJ, Bell JM, Bissette G, Nemeroff CB. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2452–5.
Slotkin, T. A., et al. “Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.Proc Natl Acad Sci U S A, vol. 87, no. 7, Apr. 1990, pp. 2452–55. Pubmed, doi:10.1073/pnas.87.7.2452.
Slotkin TA, Seidler FJ, Crain BJ, Bell JM, Bissette G, Nemeroff CB. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2452–2455.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 1990

Volume

87

Issue

7

Start / End Page

2452 / 2455

Location

United States

Related Subject Headings

  • Synaptosomes
  • Synapses
  • Organ Specificity
  • Humans
  • Choline O-Acetyltransferase
  • Choline
  • Brain
  • Autopsy
  • Alzheimer Disease