Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.
Publication
, Journal Article
Slotkin, TA; Windh, R; Whitmore, WL; Seidler, FJ
Published in: Brain Res Bull
November 1988
Catecholamines are hypothesized to control cellular development in the central nervous system. In the current study, isoproterenol administered intracisternally to neonatal rats was found to inhibit DNA synthesis [( 3H]thymidine incorporation) in brain regions. The regional selectivity of effect corresponded to the sequence of cellular maturation, namely midbrain + brainstem greater than cerebral cortex greater than cerebellum, suggesting that the specific linkage of beta-adrenergic receptors to cessation of cell replication occurs during a specific maturational stage.
Duke Scholars
Published In
Brain Res Bull
DOI
ISSN
0361-9230
Publication Date
November 1988
Volume
21
Issue
5
Start / End Page
737 / 740
Location
United States
Related Subject Headings
- Thymidine
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Isoproterenol
- DNA Replication
- Cell Division
- Cell Differentiation
- Brain
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., Windh, R., Whitmore, W. L., & Seidler, F. J. (1988). Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull, 21(5), 737–740. https://doi.org/10.1016/0361-9230(88)90040-8
Slotkin, T. A., R. Windh, W. L. Whitmore, and F. J. Seidler. “Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.” Brain Res Bull 21, no. 5 (November 1988): 737–40. https://doi.org/10.1016/0361-9230(88)90040-8.
Slotkin TA, Windh R, Whitmore WL, Seidler FJ. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull. 1988 Nov;21(5):737–40.
Slotkin, T. A., et al. “Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.” Brain Res Bull, vol. 21, no. 5, Nov. 1988, pp. 737–40. Pubmed, doi:10.1016/0361-9230(88)90040-8.
Slotkin TA, Windh R, Whitmore WL, Seidler FJ. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull. 1988 Nov;21(5):737–740.
Published In
Brain Res Bull
DOI
ISSN
0361-9230
Publication Date
November 1988
Volume
21
Issue
5
Start / End Page
737 / 740
Location
United States
Related Subject Headings
- Thymidine
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Isoproterenol
- DNA Replication
- Cell Division
- Cell Differentiation
- Brain
- Animals