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Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.

Publication ,  Journal Article
Slotkin, TA; Windh, R; Whitmore, WL; Seidler, FJ
Published in: Brain Res Bull
November 1988

Catecholamines are hypothesized to control cellular development in the central nervous system. In the current study, isoproterenol administered intracisternally to neonatal rats was found to inhibit DNA synthesis [( 3H]thymidine incorporation) in brain regions. The regional selectivity of effect corresponded to the sequence of cellular maturation, namely midbrain + brainstem greater than cerebral cortex greater than cerebellum, suggesting that the specific linkage of beta-adrenergic receptors to cessation of cell replication occurs during a specific maturational stage.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

November 1988

Volume

21

Issue

5

Start / End Page

737 / 740

Location

United States

Related Subject Headings

  • Thymidine
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Isoproterenol
  • DNA Replication
  • Cell Division
  • Cell Differentiation
  • Brain
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Slotkin, T. A., Windh, R., Whitmore, W. L., & Seidler, F. J. (1988). Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull, 21(5), 737–740. https://doi.org/10.1016/0361-9230(88)90040-8
Slotkin, T. A., R. Windh, W. L. Whitmore, and F. J. Seidler. “Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.Brain Res Bull 21, no. 5 (November 1988): 737–40. https://doi.org/10.1016/0361-9230(88)90040-8.
Slotkin TA, Windh R, Whitmore WL, Seidler FJ. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull. 1988 Nov;21(5):737–40.
Slotkin, T. A., et al. “Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.Brain Res Bull, vol. 21, no. 5, Nov. 1988, pp. 737–40. Pubmed, doi:10.1016/0361-9230(88)90040-8.
Slotkin TA, Windh R, Whitmore WL, Seidler FJ. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Res Bull. 1988 Nov;21(5):737–740.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

November 1988

Volume

21

Issue

5

Start / End Page

737 / 740

Location

United States

Related Subject Headings

  • Thymidine
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Isoproterenol
  • DNA Replication
  • Cell Division
  • Cell Differentiation
  • Brain
  • Animals