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Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.

Publication ,  Journal Article
Grignolo, A; Seidler, FJ; Bartolome, M; Kuhn, CM; Slotkin, TA; Schanberg, SM
Published in: Life Sci
December 27, 1982

The concentration and the total content of norepinephrine (NE) in the kidney were measured in Sprague-Dawley rats from 3 to 120 days after birth. Renal NE concentration was relatively low until the end of the second week, when it rose abruptly to adult levels; total NE content per kidney increased steadily throughout development. The effects of perinatal methadone treatment on renal NE development were examined by administering the drug either directly to the pups from 1 to 19 days after birth, or to the mother from 10 days of gestation to 20 days after birth. Both treatments resulted in significant deficits of body weight and kidney weight. Maternal methadone caused a significant deficit in renal NE which was most pronounced at two weeks of postnatal age; direct methadone had less effect on renal NE. These results suggest that renal sympathetic neurotransmission may become mature two weeks after birth and indicate further that maternal methadone interferes with this maturation.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

December 27, 1982

Volume

31

Issue

26

Start / End Page

3009 / 3016

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pharmacology & Pharmacy
  • Organ Size
  • Norepinephrine
  • Methadone
  • Kidney
  • Female
 

Citation

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Grignolo, A., Seidler, F. J., Bartolome, M., Kuhn, C. M., Slotkin, T. A., & Schanberg, S. M. (1982). Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone. Life Sci, 31(26), 3009–3016. https://doi.org/10.1016/0024-3205(82)90068-6
Grignolo, A., F. J. Seidler, M. Bartolome, C. M. Kuhn, T. A. Slotkin, and S. M. Schanberg. “Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.Life Sci 31, no. 26 (December 27, 1982): 3009–16. https://doi.org/10.1016/0024-3205(82)90068-6.
Grignolo A, Seidler FJ, Bartolome M, Kuhn CM, Slotkin TA, Schanberg SM. Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone. Life Sci. 1982 Dec 27;31(26):3009–16.
Grignolo, A., et al. “Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.Life Sci, vol. 31, no. 26, Dec. 1982, pp. 3009–16. Pubmed, doi:10.1016/0024-3205(82)90068-6.
Grignolo A, Seidler FJ, Bartolome M, Kuhn CM, Slotkin TA, Schanberg SM. Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone. Life Sci. 1982 Dec 27;31(26):3009–3016.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

December 27, 1982

Volume

31

Issue

26

Start / End Page

3009 / 3016

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pharmacology & Pharmacy
  • Organ Size
  • Norepinephrine
  • Methadone
  • Kidney
  • Female