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Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.

Publication ,  Journal Article
Slotkin, TA; Zhang, J; McCook, EC; Seidler, FJ
Published in: Brain Res Dev Brain Res
November 1, 1998

A recent Consensus Conference endorsed antenatal steroid use in prematurity, but indicated the need for future work on molecular and cellular effects on the developing brain. In the current study, pregnant rats were given dexamethasone during late gestation, in doses spanning those recommended for use, and effects on nuclear transcription factors were evaluated. Within the first hour after a single dose of dexamethasone, and intensifying over 4 h, marked induction of brain c-fos was seen. With repeated administration, c-fos became suppressed in some brain regions, but remained elevated in others. Dexamethasone also elicited suppression of the AP-1 family of nuclear binding proteins, but with a slower time course than seen for c-fos induction. The magnitude of the effects of late gestational exposure to dexamethasone on these transcription factors was comparable to those seen when repeated doses were administered to midgestation embryos in the context of dysmorphogenesis. Similarly, the effects on brain c-fos expression were substantially greater than those in the liver, an archetypal glucocorticoid target tissue. These results indicate that even a single, low dose of glucocorticoids used in late gestation, can disrupt the transcription factors that regulate brain cell differentiation.

Duke Scholars

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

November 1, 1998

Volume

111

Issue

1

Start / End Page

11 / 24

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Reference Values
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-fos
  • Prenatal Care
  • Pregnancy
  • Neurology & Neurosurgery
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., Zhang, J., McCook, E. C., & Seidler, F. J. (1998). Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Brain Res Dev Brain Res, 111(1), 11–24. https://doi.org/10.1016/s0165-3806(98)00115-1
Slotkin, T. A., J. Zhang, E. C. McCook, and F. J. Seidler. “Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.Brain Res Dev Brain Res 111, no. 1 (November 1, 1998): 11–24. https://doi.org/10.1016/s0165-3806(98)00115-1.
Slotkin TA, Zhang J, McCook EC, Seidler FJ. Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Brain Res Dev Brain Res. 1998 Nov 1;111(1):11–24.
Slotkin, T. A., et al. “Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.Brain Res Dev Brain Res, vol. 111, no. 1, Nov. 1998, pp. 11–24. Pubmed, doi:10.1016/s0165-3806(98)00115-1.
Slotkin TA, Zhang J, McCook EC, Seidler FJ. Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Brain Res Dev Brain Res. 1998 Nov 1;111(1):11–24.
Journal cover image

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

November 1, 1998

Volume

111

Issue

1

Start / End Page

11 / 24

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Reference Values
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-fos
  • Prenatal Care
  • Pregnancy
  • Neurology & Neurosurgery
  • Liver