Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain.
Publication
, Journal Article
McGrath, KE; Seidler, FJ; Slotkin, TA
Published in: Brain Res Dev Brain Res
December 19, 1997
Serotonin plays a trophic role in brain cell differentiation. In this study, expression of the serotonin presynaptic transporter protein, which regulates the extracellular serotonin concentration, was measured with [3H]paroxetine in rats exposed to dexamethasone or cocaine prenatally. Within 24 h of a single dose of dexamethasone, significant increases were seen in fetal brain, and the effect persisted into the postnatal period. Chronic prenatal cocaine exposure elicited similar changes. These data indicate that exposures to apparently disparate drugs can elicit similar endpoints that may lead to behavioral teratogenesis.
Duke Scholars
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
December 19, 1997
Volume
104
Issue
1-2
Start / End Page
209 / 213
Location
Netherlands
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Rats, Sprague-Dawley
- Rats
- Radioligand Assay
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Membrane Transport Proteins
- Membrane Glycoproteins
- Glucocorticoids
Citation
APA
Chicago
ICMJE
MLA
NLM
McGrath, K. E., Seidler, F. J., & Slotkin, T. A. (1997). Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain Res Dev Brain Res, 104(1–2), 209–213. https://doi.org/10.1016/s0165-3806(97)00144-2
McGrath, K. E., F. J. Seidler, and T. A. Slotkin. “Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain.” Brain Res Dev Brain Res 104, no. 1–2 (December 19, 1997): 209–13. https://doi.org/10.1016/s0165-3806(97)00144-2.
McGrath KE, Seidler FJ, Slotkin TA. Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain Res Dev Brain Res. 1997 Dec 19;104(1–2):209–13.
McGrath, K. E., et al. “Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain.” Brain Res Dev Brain Res, vol. 104, no. 1–2, Dec. 1997, pp. 209–13. Pubmed, doi:10.1016/s0165-3806(97)00144-2.
McGrath KE, Seidler FJ, Slotkin TA. Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain Res Dev Brain Res. 1997 Dec 19;104(1–2):209–213.
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
December 19, 1997
Volume
104
Issue
1-2
Start / End Page
209 / 213
Location
Netherlands
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Rats, Sprague-Dawley
- Rats
- Radioligand Assay
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Membrane Transport Proteins
- Membrane Glycoproteins
- Glucocorticoids