Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.
Publication
, Journal Article
Wood, MW; Seidler, FJ; Slotkin, TA
Published in: Res Commun Chem Pathol Pharmacol
June 1993
Oxygen therapy in preterm infants is associated with bronchopulmonary dysplasia, but the relative importance of oxygen toxicity as compared to adverse effects of intubation and mechanical ventilation, remains uncertain. In freely-breathing neonatal rats, exposure to 100% oxygen for as little as 2 hr produced a significant reduction in lung DNA synthesis, evaluated by [3H]thymidine incorporation, without a concomitant effect on [3H]leucine incorporation into protein. These results indicate that hyperoxia has a selective deleterious effect on mitosis in developing lung.
Duke Scholars
Published In
Res Commun Chem Pathol Pharmacol
ISSN
0034-5164
Publication Date
June 1993
Volume
80
Issue
3
Start / End Page
323 / 328
Location
United States
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Oxygen
- Lung
- DNA
- Animals, Newborn
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Wood, M. W., Seidler, F. J., & Slotkin, T. A. (1993). Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen. Res Commun Chem Pathol Pharmacol, 80(3), 323–328.
Wood, M. W., F. J. Seidler, and T. A. Slotkin. “Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.” Res Commun Chem Pathol Pharmacol 80, no. 3 (June 1993): 323–28.
Wood MW, Seidler FJ, Slotkin TA. Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen. Res Commun Chem Pathol Pharmacol. 1993 Jun;80(3):323–8.
Wood, M. W., et al. “Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.” Res Commun Chem Pathol Pharmacol, vol. 80, no. 3, June 1993, pp. 323–28.
Wood MW, Seidler FJ, Slotkin TA. Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen. Res Commun Chem Pathol Pharmacol. 1993 Jun;80(3):323–328.
Published In
Res Commun Chem Pathol Pharmacol
ISSN
0034-5164
Publication Date
June 1993
Volume
80
Issue
3
Start / End Page
323 / 328
Location
United States
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Oxygen
- Lung
- DNA
- Animals, Newborn
- Animals