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Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.

Publication ,  Journal Article
Bowes, C; Li, T; Danciger, M; Baxter, LC; Applebury, ML; Farber, DB
Published in: Nature
October 18, 1990

Mice homozygous for the rd mutation display hereditary retinal degeneration and the classic rd lines serve as a model for human retinitis pigmentosa. In affected animals the retinal rod photoreceptor cells begin degenerating at about postnatal day 8, and by four weeks no photoreceptors are left. Degeneration is preceded by accumulation of cyclic GMP in the retina and is correlated with deficient activity of the rod photoreceptor cGMP-phosphodiesterase. We have recently isolated a candidate complementary DNA for the rd gene from a mouse retinal library and completed the characterization of cDNAs encoding all subunits of bovine photoreceptor phosphodiesterase. The candidate cDNA shows strong homology with a cDNA encoding the bovine phosphodiesterase beta subunit. Here we present evidence that the candidate cDNA is the murine homologue of bovine phosphodiesterase beta cDNA. We conclude that the mouse rd locus encodes the rod photoreceptor cGMP-phosphodiesterase beta subunit.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 18, 1990

Volume

347

Issue

6294

Start / End Page

677 / 680

Location

England

Related Subject Headings

  • Retinal Degeneration
  • Retina
  • Polymorphism, Restriction Fragment Length
  • Photoreceptor Cells
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
 

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Bowes, C., Li, T., Danciger, M., Baxter, L. C., Applebury, M. L., & Farber, D. B. (1990). Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature, 347(6294), 677–680. https://doi.org/10.1038/347677a0
Bowes, C., T. Li, M. Danciger, L. C. Baxter, M. L. Applebury, and D. B. Farber. “Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.Nature 347, no. 6294 (October 18, 1990): 677–80. https://doi.org/10.1038/347677a0.
Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990 Oct 18;347(6294):677–80.
Bowes, C., et al. “Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.Nature, vol. 347, no. 6294, Oct. 1990, pp. 677–80. Pubmed, doi:10.1038/347677a0.
Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990 Oct 18;347(6294):677–680.

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 18, 1990

Volume

347

Issue

6294

Start / End Page

677 / 680

Location

England

Related Subject Headings

  • Retinal Degeneration
  • Retina
  • Polymorphism, Restriction Fragment Length
  • Photoreceptor Cells
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice