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Cardiopulmonary bypass time does not affect cerebral blood flow.

Publication ,  Journal Article
Croughwell, ND; Reves, JG; White, WD; Grocott, HP; Baldwin, BI; Clements, FM; Davis, RD; Jones, RH; Newman, MF
Published in: Ann Thorac Surg
May 1998

BACKGROUND: A time-dependent decline in cerebral blood flow (CBF) has been reported in cardiac surgical patients despite stable pump flows and arterial carbon dioxide tension. Other studies have failed to support these hypothermic cardiopulmonary bypass (CPB) results, showing preservation of CBF during CPB. The purpose of the study was to define the influence of mildly hypothermic CPB duration on CBF. METHODS: Cerebral blood flow was measured using xenon-133 washout and alpha-stat blood gas management during nonpulsatile CPB. Cerebral blood flow measurements were made after the initiation of CPB and near the end of bypass during pump flows of 2.4 L.min-1.m-2. RESULTS: Fifty-two coronary artery bypass patients were studied. The average time between CBF measurements was 54 +/- 20 minutes (mean +/- standard deviation), with a range of 10 to 100 minutes. Temperature and arterial carbon dioxide tension were controlled: after the initiation of CPB, temperature was 35.5 degrees +/- 0.4 degree C and carbon dioxide tension was 37 +/- 2.8 mm Hg; whereas near the end of bypass temperature was 35.6 degrees +/- 0.5 degree C and carbon dioxide tension was 36 +/- 2.3 mm Hg. We found no correlation between CBF and time on CPB (p = 0.47; r = 0.101), in contrast to other studies suggesting that CPB duration may intrinsically affect CBF. CONCLUSIONS: Our experimental results include the following: (1) during mildly hypothermic bypass, CBF does not decrease in relation to time and (2) cerebral flow-metabolism coupling is intact at 35 degrees C.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

May 1998

Volume

65

Issue

5

Start / End Page

1226 / 1230

Location

Netherlands

Related Subject Headings

  • Xenon Radioisotopes
  • Vascular Resistance
  • Time Factors
  • Respiratory System
  • Radiopharmaceuticals
  • Radionuclide Imaging
  • Oxygen Consumption
  • Oxygen
  • Multivariate Analysis
  • Middle Aged
 

Citation

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Croughwell, N. D., Reves, J. G., White, W. D., Grocott, H. P., Baldwin, B. I., Clements, F. M., … Newman, M. F. (1998). Cardiopulmonary bypass time does not affect cerebral blood flow. Ann Thorac Surg, 65(5), 1226–1230. https://doi.org/10.1016/s0003-4975(98)00113-1
Croughwell, N. D., J. G. Reves, W. D. White, H. P. Grocott, B. I. Baldwin, F. M. Clements, R. D. Davis, R. H. Jones, and M. F. Newman. “Cardiopulmonary bypass time does not affect cerebral blood flow.Ann Thorac Surg 65, no. 5 (May 1998): 1226–30. https://doi.org/10.1016/s0003-4975(98)00113-1.
Croughwell ND, Reves JG, White WD, Grocott HP, Baldwin BI, Clements FM, et al. Cardiopulmonary bypass time does not affect cerebral blood flow. Ann Thorac Surg. 1998 May;65(5):1226–30.
Croughwell, N. D., et al. “Cardiopulmonary bypass time does not affect cerebral blood flow.Ann Thorac Surg, vol. 65, no. 5, May 1998, pp. 1226–30. Pubmed, doi:10.1016/s0003-4975(98)00113-1.
Croughwell ND, Reves JG, White WD, Grocott HP, Baldwin BI, Clements FM, Davis RD, Jones RH, Newman MF. Cardiopulmonary bypass time does not affect cerebral blood flow. Ann Thorac Surg. 1998 May;65(5):1226–1230.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

May 1998

Volume

65

Issue

5

Start / End Page

1226 / 1230

Location

Netherlands

Related Subject Headings

  • Xenon Radioisotopes
  • Vascular Resistance
  • Time Factors
  • Respiratory System
  • Radiopharmaceuticals
  • Radionuclide Imaging
  • Oxygen Consumption
  • Oxygen
  • Multivariate Analysis
  • Middle Aged