Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
Publication
, Journal Article
Pupillo, M; Kumagai, A; Pitt, GS; Firtel, RA; Devreotes, PN
Published in: Proc Natl Acad Sci U S A
July 1989
Previous results have shown that chemotaxis and the expression of several classes of genes in Dictyostelium discoideum are regulated through a cell surface cAMP receptor interacting with guanine nucleotide-binding proteins (G proteins). We now describe cloning and sequencing of cDNAs encoding two G alpha protein subunits from Dictyostelium. The derived amino acid sequences show that they are 45% identical to each other and to G alpha protein subunits from mammals and yeast. Both cDNAs are complementary to multiple mRNAs that are differentially expressed during development. This evidence and analysis of mutants presented elsewhere suggest that they have distinct physiological functions.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 1989
Volume
86
Issue
13
Start / End Page
4892 / 4896
Location
United States
Related Subject Headings
- Transducin
- Sequence Homology, Nucleic Acid
- Molecular Sequence Data
- Macromolecular Substances
- Genes, Fungal
- Genes
- GTP-Binding Proteins
- Dictyostelium
- Cloning, Molecular
- Base Sequence
Citation
APA
Chicago
ICMJE
MLA
NLM
Pupillo, M., Kumagai, A., Pitt, G. S., Firtel, R. A., & Devreotes, P. N. (1989). Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. Proc Natl Acad Sci U S A, 86(13), 4892–4896. https://doi.org/10.1073/pnas.86.13.4892
Pupillo, M., A. Kumagai, G. S. Pitt, R. A. Firtel, and P. N. Devreotes. “Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.” Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 4892–96. https://doi.org/10.1073/pnas.86.13.4892.
Pupillo M, Kumagai A, Pitt GS, Firtel RA, Devreotes PN. Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4892–6.
Pupillo, M., et al. “Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.” Proc Natl Acad Sci U S A, vol. 86, no. 13, July 1989, pp. 4892–96. Pubmed, doi:10.1073/pnas.86.13.4892.
Pupillo M, Kumagai A, Pitt GS, Firtel RA, Devreotes PN. Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4892–4896.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 1989
Volume
86
Issue
13
Start / End Page
4892 / 4896
Location
United States
Related Subject Headings
- Transducin
- Sequence Homology, Nucleic Acid
- Molecular Sequence Data
- Macromolecular Substances
- Genes, Fungal
- Genes
- GTP-Binding Proteins
- Dictyostelium
- Cloning, Molecular
- Base Sequence