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Ependymomas: MIB-1 proliferation index and survival.

Publication ,  Journal Article
Ritter, AM; Hess, KR; McLendon, RE; Langford, LA
Published in: J Neurooncol
October 1998

The biologic behavior of ependymomas is highly variable, and its correlation with histologic features is at best imprecise. This retrospective study attempted to correlate the malignant histologic characteristics of ependymomas with MIB-1 proliferation index and survival. Biopsy and resection specimens taken from 34 patients who received treatment 1972 to 1996 were histologically examined. The patients' ages range was 1 to 59 years. The histologic specimens were assessed for anaplastic features (necrosis, mitosis, vascular proliferation, cellular pleomorphism, and overlapping of nuclei) and an MIB-1 (Ki-67 antigen) proliferation index was also determined. The overall median MIB-1 proliferation index was 7.8% (range 0.1 - 62.5%). An MIB-1 of 20% was significant for a decrease in survival (RR = 5.7) (p = 0.0013). The median MIB-1 for patients < 20 years old was 20.6% with range (0.1, 43%), while that for patients > 20 years was 5.1% (range 0.2, 9.4%) (KW p = 0.055). Three of 5 histological features evaluated were significantly associated with outcome: > 5 mitotic figures per high-power field, necrosis, and vascular proliferation, but not nuclear overlap or pleomorphism. All pathologic factors except pleomorphism were significantly related to the MIB-1 proliferation index. In brief, our data support the association of poor prognoses in ependymomas with young age, the presence of three to four anaplastic histologic features, and an MIB-1 proliferation index > 20%.

Duke Scholars

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

October 1998

Volume

40

Issue

1

Start / End Page

51 / 57

Location

United States

Related Subject Headings

  • Survival Analysis
  • Spinal Cord Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Ki-67 Antigen
  • Infant
  • Humans
 

Citation

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Ritter, A. M., Hess, K. R., McLendon, R. E., & Langford, L. A. (1998). Ependymomas: MIB-1 proliferation index and survival. J Neurooncol, 40(1), 51–57. https://doi.org/10.1023/a:1006082622699
Ritter, A. M., K. R. Hess, R. E. McLendon, and L. A. Langford. “Ependymomas: MIB-1 proliferation index and survival.J Neurooncol 40, no. 1 (October 1998): 51–57. https://doi.org/10.1023/a:1006082622699.
Ritter AM, Hess KR, McLendon RE, Langford LA. Ependymomas: MIB-1 proliferation index and survival. J Neurooncol. 1998 Oct;40(1):51–7.
Ritter, A. M., et al. “Ependymomas: MIB-1 proliferation index and survival.J Neurooncol, vol. 40, no. 1, Oct. 1998, pp. 51–57. Pubmed, doi:10.1023/a:1006082622699.
Ritter AM, Hess KR, McLendon RE, Langford LA. Ependymomas: MIB-1 proliferation index and survival. J Neurooncol. 1998 Oct;40(1):51–57.
Journal cover image

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

October 1998

Volume

40

Issue

1

Start / End Page

51 / 57

Location

United States

Related Subject Headings

  • Survival Analysis
  • Spinal Cord Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Ki-67 Antigen
  • Infant
  • Humans